BACKGROUND Hemispheric lateralization of the brain occurs during development and underpins specialized functions. It is posited that aberrant neurodevelopment leads to abnormal brain lateralization in individuals with psychotic illnesses. Here, we sought to examine whether white matter hemispheric lateralization is abnormal in individuals with the psychotic spectrum disorders of schizophrenia a...

psychosis, a relatively common condition that affects 3%-5% percent of the population, occurs in a variety of diagnostic contexts. various medical conditions may lead to the development of psychotic symptoms. to date psychotic disorders due to infection with hepatitis a virus (hav) have â been â rarely reported. in this paper, we described an acute psychotic disorder in an 18-year-old male diag...

psychotic disorders and bipolar disorder (8) and between bipolar disorder and major depressive disorder (9). Although family and twin studies can estimate the shared heritability across disorders, they cannot identify the genetic loci contributing to this overlap. To date, evidence implicating specifi c chromosomal regions and genes in the shared liability to psychotic and mood disorders has la...

IMPORTANCE Psychotic disorders (including schizophrenia, schizoaffective disorder, and psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the integration of information processing. Recent advances in neuroimaging allow for the estimation of brain networks on the basis of intrinsic functional connectivity, but the specific network abnormalities in psychotic disor...

abstract: introduction: psychiatric disorder is a disease in which patients suffer from emotional problems that these are visible in all aspect of patient’s life. studies show that there is a major difference between the prevalence of this disease in different countries and also show that this disorder is increasing. the aim of this study is to find the possible relationship between psychiatric...

To investigate whether aberrant interactions between brain structure and function present similarly or differently across probands with psychotic illnesses [schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar I disorder with psychosis (BP)] and whether these deficits are shared with their first-degree non-psychotic relatives. A total of 1199 subjects were assessed, including 220 SZ,...

The prevalence of obsessive-compulsive disorder in subjects with psychotic disorder is much higher than in the general population. The higher than chance co-occurrence has also been demonstrated at the level of subclinical expression of both phenotypes. Both extended phenotypes have been shown to cluster in families. However, little is known about the origins of their elevated co-occurrence. In...

BACKGROUND Controversy remains as to whether cannabis acts as a causal risk factor for schizophrenia or other functional psychotic illnesses. AIMS To examine critically the evidence that cannabis causes psychosis using established criteria of causality. METHOD We identified five studies that included a well-defined sample drawn from population-based registers or cohorts and used prospective...

BACKGROUND Although they were once considered separate nosologic entities, there is current interest in the etiologic overlap between bipolar disorder (BD) and schizophrenia. A critical issue concerns the familial basis of the overlap, specifically, the possibility of a distinct familial subtype of BD with psychotic features. METHODS We recruited individuals with BD from the community and com...