The effects of therapeutic doses of dillsun, garsin, antum and statins on rat liver cytosolic phosphatidate phosphohydrolase (PAP) activity, a key enzyme in triacylglycerol synthesis, and on serum and liver lipids were examined. Lovastatin and simvastatin both stimulated the enzyme activity by 29% and 43%, respectively. The stimulatory effects were dose-dependent and accompanied by the decline ...

Opting an appropriate dietary regime has been and will be one of the simplest ways of providing health for and preventing disorders of human beings. Cardiovascular diseases-one of the most prevalent causes of morbidity and mortality worldwide-are in particular related to diet. Atherosclerosis, the most common pathogenic process of cardiovascular disease, is closely connected with food ingredien...

That hyperlipemia may be responsible for atherosclerosis has long been hypothecated on the grounds of what might be termed circumstantial evidence. The first experimental proof of this concept was provided by Anitschkow's demonstration in 1913 that atheroma can be produced in rabbits by feeding cholesterol. In recent years similar lesions have been induced by similar methods in five other speci...

Serum cholesterol, serum glyceride, blood glucose, relative weight, physical activity, percent calories from fat, percent calories from carbohydrate, and polyunsaturated/saturated fatty acid (P/S) ratio were determined in 1780 rural and 4023 urban fasting men aged 45-64 years being followed prospectively to ascertain reasons for the low prevalence of coronary heart disease mortality in Puerto R...

men at comparable ages. Hyperlipoproteinemia, cholesterol, and triglyceride elevations were more common in MI patients than in men in the random sample, occurring with greatest frequency in the younger patients. There was a trend toward higher mortality among patients with hyperlipoproteinemia. Types II A and B were very common in young patients. Serum cholesterol values were significantly high...