human serum albumin has been used as a model protein for protein folding and ligand binding studies over many decades. due to its long life period and high concentration in plasma, hsa is highly sensitive to glycation. it is reported that 175 mg/dl glucose concentration is a threshold of kidney activity for the beginning of excretion of glucose. ph denaturation of hsa in absence and presence of...

Introduction: The Serum/Glucose deprivation -induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders. Nigella sativa L. has been known as a source of antioxidants. To elucidate the neuroprotective actions of N. sativa extract in vitro, we studied the effect of N. sativa extract on cultured PC12 cells under s...

Objective: Diabetes mellitus is a multifactorial metabolic disorder that affects multiple organs of the body, one of the most important of which is chronic kidney disease. Early diagnosis of this disease is suggested as an important strategy to reduce the complications of the disease worldwide. Since the measurement of salivary creatinine and glucose is an easy and noninvasive method, the aim o...

conclusions overall, the results of this study indicate that intermittent exercise reduces the plasma leptin level. in addition, this reduction is significantly correlated to the glucose level in the blood. the continuous exercise was shown to have no effects on the plasma leptin level, and there was no relationship between the glucose and leptin levels. results the results demonstrated that se...

conclusions based on these data, we can argue that circulating glucose concentration is not directly affected by serum resistin in t2dm. it seems that resistin affects glucose indirectly, through insulin resistance. results we found that serum resistin had a positive significant correlation with insulin resistance (p = 0.000, r = 0.64). no significant correlation was found between serum resisti...

background: hyperglycemia is one of the important featurs of diabetes. in cell culture studies different methods are used to mimic the hyperglycemia condition. in this study we investigate response of human liver cancer cell line (hepg2) to high insulin, high glucose, and high insulin/ high glucose medium exposure. methods: hepg2 cells were settled in dmem+0.1% fbs or dmem free-serum medium wit...

coenzyme q 10 is a natural antioxidant and free radicals scavenger. in the present study, we examined effect of coenzyme q 10 on hemoglobin a 1c , serum urea and creatinine in alloxan-induced type 1 diabetic rats. thirty sprage-dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with coenzyme q 10 (15 mg/kg i...

some recent studies have revealed the relationship among excess ferritin, coronary heart disease, and insulin resistance. to assess the association between serum ferritin concentration and impaired fasting glucose, this study was designed. a total of 187 people including 91 impaired fasting glucose (ifg) subjects and 96 normal glucose subjects who had been recognized in a large epidemiological ...