vincristine (vcr) as a frequently used antimitotic agent which is commonly prescribed for wide spectrum of neoplasm, causes mixed sensorimotor neuropathy. several evidences show lithium could be a neuroprotective agent, therefore to assess whether a pretreatment and at subtherapeutic dose it could prevent the peripheral neuropathy produced by vcr, rats were treated with vcr 0.1mg/kg i.p. for 3 ...

#### Notable in Neurology This Week issue features an article that examines the perspectives of patients with myasthenia gravis on severity their symptoms; another investigates predictors early neurologic deterioration lacunar stroke. A featured Special Article presents American Academy Neurology's position high drug costs and distributive justice. ### Pure Motor Onset IgM-Gammopathy Occurrence...

•N2O toxicity and B12 deficiency both cause a sensory predominant myeloneuropathy. abuse may also lead to selectively severe motor axonal peripheral neuropathy. •This neuropathy phenotype be related N2O direct neural toxicity. •In-vivo measures of dysfunction are more pronounced in abuse.

The authors describe two patients with acute sensory ataxic neuropathy. Both had a profound loss of proprioception and generalized areflexia. High titers of monospecific anti-GD1b IgG antibody were detected in their sera during the acute phase. Sensory ataxia resolved within 2 weeks after the onset. Taken together with the induction of experimental sensory ataxic neuropathy sensitized with GD1b...

OBJECTIVES To investigate the reproducibility of measured indices of chronic peripheral neuropathy from a field study of sheep dippers when compared with similar measurements carried out in a clinical setting. METHODS A stratified random sample of field study subjects was invited to attend a clinic. Neuropathy was measured both in the field and at the clinic with a modified version of a stand...

Peripheral sensory neuropathy and its risk factors are well-described in adults with type 1 diabetes (T1D). While clinically evident neuropathy is rare in young people with T1D, we and others have shown that subclinical peripheral neuropathy is common [1]. However, the prevalence of sensory neuropathies may be underestimated, due to a lack of established testing guidelines. We performed a syste...