A dilute solution of procaine in glucose solution was injected by slow drip into the lumbar theca of patients to cause a differential block. Vasodilatation of the skin vessels of the lower limbs always occurred before any change in sensibility. The first changes in sensibility were inability to fell painful stimuli and warm stimuli; these two forms of sensibility were usually coextensive and oc...

This review is based on the Theophilus Redwood Medal and Award lectures, delivered to Royal Society of Chemistry meetings in the UK and Ireland in 2012, and presents a personal overview of the field of biosensors. The biosensors industry is now worth billions of United States dollars, the topic attracts the attention of national initiatives across the world and tens of thousands of papers have ...

For over 15 years, antisense morpholino oligonucleotides (MOs) have allowed developmental biologists to make key discoveries regarding developmental mechanisms in numerous model organisms. Recently, serious concerns have been raised as to the specificity of MO effects, and it has been recommended to discontinue their usage, despite the long experience of the scientific community with the MO too...

2007/Jul/02 Sensibility of quorum growth thresholds controlling local immune responses – p. 2007/Jul/02 Sensibility of quorum growth thresholds controlling local immune responses – p. 2/36 Motivation 2007/Jul/02 Sensibility of quorum growth thresholds controlling local immune responses – p. 3/36 Immune system Leukocytes (white blood cells) circulate in the blood Leukocytes are produced in the b...

A handy thermal sensibility testing device has been developed and field tested in different centres in Africa and India. The device performed satisfactorily under field conditions and made testing for thermal sensibility in the field practicable and easy. Examination of the results of testing 260 persons, most of them having a few lesions of early leprosy, showed that the expected increase in t...