نتایج جستجو برای: senescence
تعداد نتایج: 19206 فیلتر نتایج به سال:
Objective(s): Hyperglycemia induces cellular senescence in various body cells, such as vascular endothelial cells. Since the vessels are highly distributed in the body and nourish all tissues, vascular damages cause diabetes complications such as kidney failure and visual impairment. Alpha-mangostin is a xanthone found in mangosteen fruit with protective effects in met...
Background: Chronic hyperglycemia is associated with an increase in cellular damage due to oxidative stress and increases insulin resistance and also increases in p53 and p16 beta cells, leading to the induction of senescence in pancreatic insulin-secreting cells. The aim of this study was the effect of eight weeks of aerobic exercise on the expression of senescence proteins P53 and P16 in the ...
Senescence-resumed proliferation (SRP) is proposed to be a mechanism associated with the escape of p21-mediated senescence and activation Wnt/β-catenin pathways that enhance malignancy. The keloid genomic landscape shows heavy intersections between TP53 TGF-β signaling. machinery maintain cellular integrity through senescence, apoptosis, autophagy co-regulated stemness, hedgehog, immunomodulati...
getting old is not a sickness. it is actually a social-personal experience and one of the sensitive and vital stages of human development that is regarded as a normal trend of passing of life. anxiety is among the major problems of senescent period. research shows that the memory of group treatment among the elderly is not only useful but also considered as a type of treatment. this method help...
Senescence is an irreversible cell-cycle arrest process induced by environmental, genetic, and epigenetic factors. An accumulation of senescent cells in bone results age-related disorders, one the common problems osteoporosis. Deciphering basic mechanisms contributing to chronic ailments aging may uncover new avenues for targeted treatment. This review focuses on most relevant research advancem...
Plant hormones strigolactones (SLs) were recently reported to induce leaf senescence. It was that sugar suppresses SL-induced senescence in the dark; however, mechanism of crosstalk between SLs and signal remains elusive. To understand this mechanism, we studied effects glucose (Glc) on various senescence-related parameters leaves rice. We found sugars alleviated under dark conditions, co-treat...
this experiment was conducted to quantify leaf production and senescence in wheat. the experiment was carried out at research farm of the gorgan university of agricultural sciences and natural resources, gorgan, iran in 2005 using a randomized complete design considering sowing dates as environment. treatments were sowing date (14 december, 20 jan and 21 feb, 2005) and cultivars (aria, atrak, k...
Senescence, a state of stable growth arrest, plays an important role in ageing and age-related diseases vivo. Although the INK4/ARF locus is known to be essential for senescence programmes, key regulators driving p16 ARF transcription remain largely underexplored. Using siRNA screening modulators p16/pRB ARF/p53/p21 pathways deeply senescent human mammary epithelial cells (DS HMECs) fibroblasts...
BACKGROUND Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through senescence and DNA damage response (DDR). We examined the association between senescence and DDR with macrophage levels in inflammatory bowel disease (IBD). In vitro experiments tested the ability of macrophages to induce senescence in primary cells. I...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید