Epilepsy is a neurological condition which is characterized by unprovoked seizures resulting from abnormal discharge of cerebral neurons and affecting at least 50 million people worldwide. There is continuing demand for new anticonvulsant agents as it has not been possible to control every kind of seizure with existing antiepileptic drugs. Moreover, conventional antiepileptic drugs exhibited un...

In the title compound, C(9)H(11)N(3)O·CH(4)O, the semicarbazone moiety is nearly planar [maximum deviation = 0.017 (2) Å] and is twisted by a dihedral angle of 29.40 (13)° with respect to the phenyl ring. The semicarbazone moiety and phenyl ring are located on opposite sides of the C=N bond, showing the E configuration. An inter-molecular O-H⋯O and N-H⋯O hydrogen-bonding network occurs in the c...

Reaction between the NH4VO3 and pyridoxal semicarbazone (PLSC) in a methanol/ammonia solution forms an orange, diamagnetic, mononuclear NH4[VO2(PLSC-2H)] complex in which vanadium is in the oxidation state +5, and pyridoxal semicarbazone is coordinated in its dianionic form. The complex cocrystallizes with a neutral molecule of PLSC and two water molecules. The coordination environment around v...

Fig, 1: Structure of phenylaceticacid hydrazones and 2-chlorophenylsemicarbazones. Antidepressant activity was evaluated in albino rats weighing 100 to 120 g, by Porsolt forcecll swimming test (4). Rats were individually placed in plexiglass cylinders (height 40 cm; diameter 18 cm), containing 15 cm of water maintained at 25°C. After 15 minutes they were removed to a 30°C drying room for 30 min...

The title compound, C(12)H(11)N(3)O(2), adopts an E or trans configuration with respect to the C=N bond. There is an intra-molecular O-H⋯N hydrogen bond involving the hydroxyl H atom and an N atom of the hydrazine group. In the crystal structure, mol-ecules are connected via N-H⋯O hydrogen bonds, forming a three-dimensional network.

In the title compound, C(9)H(10)BrN(3)O, the hydrazone portion and aliphatic chain are essentially coplanar [maximum deviation 0.057 (15) Å] and the mean plane makes a dihedral angle of 70.9 (6)° with the benzene ring. The main feature of the crystal structure is the inter-molecular N-H⋯O hydrogen bond, which links mol-ecules into zigzag chains along the a axis. These chains are further stacked...

The title compound, C(13)H(12)N(4)O, crystallizes with two independent mol-ecules in the asymmetric unit. The compound crystallizes as the ZE isomer, where Z and E refer to the configuration around the C=N and N-C bonds, respectively, with an N-H⋯N(py) (py is pyridine) intra-molecular hydrogen bond. The dihedral angles between the least-squares planes through the semicarbazone group and the pyr...

The mol-ecule of the title compound, C(12)H(15)N(3)O(2)S, which belongs to the family of thio-semicarbazones, containing an acid group, adopts a semi-closed conformation with an intramolecular N-H⋯N hydrogen bond. In the crystal, molecules are linked by strong N-H⋯O and O-H⋯S hydrogen bonds between the acid group and thiosemicarbazone unit, with one additional intermolecular hydrogen C-H⋯O inte...

Effective methodologies for efficient preparation of semicarbazones from aldehydes or ketones via milling and the subsequent regeneration of the parent carbonyls by gaseous nitrogen dioxide are described under solid-solid and gas-solid reaction conditions, respectively. These methods are fast, simple and environmentally benign which do not require the use of any auxiliaries such as catalyst...