BACKGROUND Selenium, a potential cancer prevention agent currently being tested against prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT), plays an integral role in thyroid metabolism. The effects of long-term selenium supplementation on thyroid hormone concentrations are unknown. OBJECTIVE The objective was to investigate the effects of long-term selenium supplem...

background: given to the abundant incidence of malnutrition in hiv+ patients and its effect on progress of aids disease, several studies have recommended supplementation therapy (such as selenium, levamisole, zinc). methods: this clinical trial was prefunded on patient's with hiv + in behavior diseases consulting center, kermanshah, iran 2006-2007. one hundred-seventy eight out of all pati...

Selenium is an essential trace nutrient required for the synthesis of selenoproteins such as glutathione peroxidase and thioredoxin reductase, the major forms of selenium in the endothelium that have important functions relevant to inflammation and cardiovascular disease. Selenium deficiency is associated with cardiomyopathy and sudden cardiac death in animals, and a low selenium status is asso...

OBJECTIVE To evaluate selenium dietary intake and nutritional status of patients with phenylketonuria. METHODS The study prospectively evaluated 54 children with phenylketonuria, from 4 to10 years old. The study was performed before and after the use of a selenium-supplemented amino acid mixture. The second phase of the study was performed after, at least, 90 days of use of the supplementatio...

BACKGROUND Patients with sepsis syndrome commonly have low serum selenium levels. Several randomized controlled trials have examined the efficacy of selenium supplementation on mortality in patients with sepsis. OBJECTIVE To determine the efficacy and safety of high-dose selenium supplementation compared to placebo for the reduction of mortality in patients with sepsis. SOURCES OF DATA We s...

Selenium is a non-metallic chemical element of great important to human health. Low selenium levels in humans are associated with several pathological conditions and are a common finding in HIV infected individuals. We conducted a review of the literature to assess if selenium deficiency or selenium supplementation could play a role in modifying the clinical course of HIV disease. Several studi...

Sakr and colleagues report seemingly disappointing data on the effects of selenium in severe sepsis [1]. Mortality rates remained unaffected despite intensive selenium supplementation. The authors conclude that extra selenium above a basal supply of 100 μg/day provides no additional health benefit. However, there are good reasons for selenium supplementation in sepsis; the selenium status decli...

The antioxidant capacity of the glutathione redox cycle and the concentrations of selenium in serum, red blood cells or whole blood, and polymorphonuclear leucocytes was evaluated in nine patients with severe rheumatoid arthritis (RA) and eight healthy controls receiving daily supplementation with 250 micrograms selenomethionine for six months. Serum and whole blood concentrations of selenium a...

OBJECTIVE To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities. METHODS Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented ...

We appreciate the opportunity to respond to the letter from Drs Bekaert and Rayman regarding our recently published article (1) on the association between plasma selenium concentrations and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Bekaert and Rayman point out that the mean plasma selenium concentration of EPIC participants is lower than th...