The Se-dependent expression of two selenoproteins, cytosolic glutathione peroxidase (cGPx) and type I iodothyronine-5'-deiodinase (5'DI), was investigated in the porcine epithelial kidney cell line LLC-PK1 in serum-free medium. The selenite-dependent expression of cGPx and 5'DI was revealed by enzyme-activity measurements, affinity labelling of 5'DI, metabolic labelling of proteins with 75Se an...

Selenium (Se) is an essential micro-nutrient for living organisms, but elevated concentrations in water can adversely affect health. In this research, we investigate the removal of selenium oxyanions (selenate and selenite) aqueous systems by integration adsorption on modified zeolites microbial reduction. Dynamic sorption-reduction experiments were conducted using two sets zeolite columns sele...

The efficiency of strontium selenite and selenite F broths in the isolation of S. typhi from 625 clinical stool specimens were compared. A total of 126 strains of S. typhi were detected. Of these, 96 (76%) were isolated with selenite F broth and 118 (94%) were isolated with strontium selenite broth. At the same time, the number of false positive isolates accruing to strontium selenite broth was...

The concentration of Se in algal cells is a primary determinant of Se tissue contents in higher level consumers. Differences in the ability of algal species to concentrate selenite and variability in ambient selenite concentrations may be important determinants of algal Se contents. We compared uptake of 75Se-labeled selenite by 14 algal species at 2 environmentally relevant selenite concentrat...

• Selenite is a predominant form of selenium (Se) available to plants, especially in anaerobic soils, but the molecular mechanism of selenite uptake by plants is not well understood. • ltn1, a rice mutant previously shown to have increased phosphate (Pi) uptake, was found to exhibit higher selenite uptake than the wild-type in both concentration- and time-dependent selenite uptake assays. Respi...

The aim of this study was to evaluate the radioprotector effect of sodium selenite on the ultrastructure of submandibular glands in rats. Fifty-seven male albino Wistar rats were randomized to 4 groups: control, irradiated, sodium selenite and irradiated/sodium selenite. The animals in the sodium selenite and irradiated/sodium selenite groups received intraperitoneal injections of sodium seleni...

Although the anticancer effects of selenium have been shown in clinical, preclinical, and laboratory studies, the underlying mechanism(s) remains unclear. Our previous study showed that sodium selenite induced LNCaP human prostate cancer cell apoptosis in association with production of reactive oxygen species, alteration of cell redox state, and mitochondrial damage. In the present study, we sh...

Removal of selenium oxyanions by the binary oxide systems, Al- or Fe-oxides mixed with X-ray noncrystalline SiO(2), was previously not well understood. This study evaluates the adsorption capacity and kinetics of selenium oxyanions by different metal hydroxides onto SiO(2), and uses X-ray absorption spectroscopy (XAS) to assess the interaction between selenium oxyanions and the sorbents at pH 5...

The effect of selenite administered at various time intervals after mercury treatment on the toxicity and renal content of mercuric mercury in mice was studied. A marked protective effect of selenite on growth depression and renal lesions caused by mercuric chloride was observed in mice receiving mercury and selenite simultaneously. However, growth depression was not protected by post administr...

Although selenium compounds have been extensively studied as chemopreventative agents for prostate cancer, little is known about the potential use of selenium compounds for chemotherapy. We have shown that selenite inhibits cell growth and induces apoptosis in androgen-dependent LAPC-4 prostate cancer cells. LAPC-4 cells were more sensitive to selenite-induced apoptosis than primary cultures of...