نتایج جستجو برای: selective cox 2 inhibitors

تعداد نتایج: 2821211  

A.H Ebrahimabadi H Irannejad

Introduction: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are used in treating pathologic conditions such as fever, pain and inflammation by inhibiting cyclooxygenase and consequently prostaglandin production. Recently , the discovery of different isoforms of this enzyme, Cyclooxygenase-1 (COX-1) and Cyclooxygense-2 (COX-2), has led to the synthesis and introduction of novel drugs with selec...

Journal: :journal of pharmaceutical and health sciences 0

a group of 1,3-biarylhydrazide derivatives possessing a cox-2 azido pharmacophore at the para- position of the c-1 phenyl ring in conjunction with a n-3 phenyl or substituted-phenyl ring (4-f,4-cl,4-ome) were designed and synthesized based on nucleophilic substitution reaction. a molecular modelling study of these compounds showed that the designed molecules were well bound with the active site...

Journal: :iranian journal of pharmaceutical research 0
afshin zarghi shahid beheshti univ. med. sci. iman sabakhi department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences vigen topuzyan the scientific thechnological centre of organic and pharmaceutical chemistry nasraal. mnjoyan institute of fine organic chemistry, yerevan, armenia. zahra hajimahdi department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences bahram daraei department of toxicology, faculty of medical sciences, tarbiat modares university hadi arefi department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

as a continuous research for discovery of new cox-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of anew group of 1,4-dihydropyridine (dhp) derivatives were presented. novel synthesized compounds possessing a cox-2 so2me pharmacophore at the para position of c-4 phenyl ring, different hydrophobic groups (r1) at c-2 position and alkoxycarbonyl groups (...

As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of anew group of 1,4-dihydropyridine (DHP) derivatives were presented. Novel synthesized compounds possessing a COX-2 SO2Me pharmacophore at the para position of C-4 phenyl ring, different hydrophobic groups (R1) at C-2 position and alkoxycarbonyl groups (...

As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of anew group of 1,4-dihydropyridine (DHP) derivatives were presented. Novel synthesized compounds possessing a COX-2 SO2Me pharmacophore at the para position of C-4 phenyl ring, different hydrophobic groups (R1) at C-2 position and alkoxycarbonyl groups (...

Mohammad Khaksari, Nader Shahrokhi Zakieh Keshavarzi

Objective(s):This study was carried out to investigate the effects of COX-2 selective inhibitor (Celecoxib) or non-selective COX inhibitor (Ibuprofen) on gastrointestinal motility. Materials and Methods: The rats were randomly divided into five groups including: intact, sham, traumatic brain injury (TBI) group (intact rats under TBI), Celecoxib group (10 mg/kg), Ibuprofen group (10 mg/kg). Rats...

Journal: :iranian journal of pharmaceutical research 0
afshin zarghi department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran iman sabakhi the scientific thecnological centre of organic and pharmaceutical chemistry nasraal. mnjoyan institute of fine organic chemistry, yerevan, armenia vigen topuzyan the scientific thecnological centre of organic and pharmaceutical chemistry nasraal. mnjoyan institute of fine organic chemistry, yerevan, armenia zahra hajimahdi department of pharmaceutical chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran bahram daraie department of toxicology, school of medicine, tarbiat modarres university of medical sciences, tehran, iran

a group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a cox-2 so2me pharmacophore at the para position of the c-2 or c-4 phenyl ring, in conjunction with a c-4 or c-2 phenyl (4-h) or substituted-phenyl ring (4-f,4-cl,4-br,4-ome,4-me, 4-no2), were designed for evaluation as selective cyclooxygenase-2 (cox-2) inhibitors. these target 5-oxo-1,4,5,6,7,8 hexahydroquino...

Journal: :iranian journal of basic medical sciences 0
zakieh keshavarzi department of physiology, north khorasan university of medical sciences, bojnurd, iran mohammad khaksari department of physiology, kerman university of medical sciences, kerman, iran nader shahrokhi department of physiology, kerman university of medical sciences, kerman, iran

objective(s):this study was carried out to investigate the effects of cox-2 selective inhibitor (celecoxib) or non-selective cox inhibitor (ibuprofen) on gastrointestinal motility. materials and methods: the rats were randomly divided into five groups including: intact, sham, traumatic brain injury (tbi) group (intact rats under tbi), celecoxib group (10 mg/kg), ibuprofen group (10 mg/kg). rats...

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