Sperm DNA fragmentation has been associated with reduced fertilization rates, embryo quality, pregnancy rates and increased miscarriage rates. Various methods exist to test sperm DNA fragmentation such as the sperm chromatin structure assay (SCSA), the sperm chromatin dispersion (SCD) test, the terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labelling (TUNEL) a...

INTRODUCTION Sperm chromatin integrity assessment has been suggested as a fertility predictor. The aim of this study was to examine the relationship between the results of sperm chromatin structure assay (SCSA) and the outcome of IVF, ICSI and intrauterine insemination (IUI). METHODS A total of 306 consecutive couples undergoing assisted reproduction were included. IUI was performed in 131, I...

OBJECTIVE This study evaluated the integrity of the chromatin structure, reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), DNA damage and lipid peroxidation of semen samples from infertile men classified as unexplained infertility. METHODS Between February 2010 and July 2011 semen parameters and functional tests were evaluated in 10 subjects with proven fertility, ...

Aim: To investigate the prevalence of high levels of sperm DNA damage among men from infertile couples with both normal and abnormal standard semen parameters. Methods: A total of 350 men from infertile couples were assessed. Standard semen analysis and sperm chromatin structure assay (SCSA) were carried out. Results: Ninety-seven men (28% of the whole study group) had a DNA fragmentation index...

Studies over the past two decades have clearly shown that reproductive toxicants cause sperm DNA fragmentation. This DNA fragmentation can usually be detected prior to observing alterations of metaphase chromosomes in embryos. Thus, Sperm Chromatin Structure Assay (SCSA)-detected DNA damage is viewed as the molecular precursor to later gross chromosome damage observed under the light microscope...

Shifted-Chebyshev-series approach (SCSA) and hybrid Taguchi-genetic algorithm (HTGA) were integrated into a Takagi-Sugeno (TS) fuzzy model nonlinear human immunodeficiency virus (HIV) dynamics. Since only the algebraic computations in SCSA were applied in the TS fuzzy model-based dynamic equations, the proposed model simplified the problem by transforming it into a static optimization problem r...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Dr. Ward in his commentary summarized the currently available sperm DNA fragmentation (SDF) tests. He classified the eight SDF assays into four groups based on the different target sites and illustrated the grouping in a diagram to simplify understanding of the readers (1). We would like to supplement, in the followin...

The performance evaluation of supply chain strategy alliance (SCSA) has the novelty compares with the traditional enterprise organization form under electronic commerce environment. This paper constructs a set of systematic SCSA evaluating indices system that included four aspects of customer and node enterprise satisfaction, supply chain operation flow, supply chain economic benefit, supply ch...

Spectrum auction is an enabling technology for improving the spectrum efficiency of unused licensed bands (white spaces) in wireless networks. However, the back-room dealing (i.e., the frauds of the untrustworthy auctioneer and the bid-rigging between the greedy bidders and the insincere auctioneer) poses serious security challenges, leading to failures of all existing secure auction designs in...