Introduction Although it is a rare disorder, scleromyxedema (lichen myxedematosus) is one of the most common forms of primary cutaneous mucinosis. This condition is a generalized form of dermal mucin deposition characterized by waxy papules that progresses to indurated and thickened skin and is often associated with monoclonal gammopathy, particularly of the immunoglobulin G type. Lichen myxede...

Scleromyxedema is part of a group of cutaneous mucinoses, characterized by a generalized papular eruption, dermal mucin deposition, and an increase in dermal collagen. This condition can be localized as discrete papular lichen myxedematous skin or as a systemic condition usually associated with paraproteinaemia. To date, there is no unifying treatment and is limited by rarity, small number of c...

A 49-year-old farmer presented with papules on the face, arms, chest and back associated with sclerosis. Histopathology and PAS stain confirmed the clinical diagnosis of scleromyxedema. He also had elevated CPK levels due to myopathy. Screening for internal malignancy was negative.

Scleromyxedema is a chronic, progressive condition characterised by dermal fibrosis and mucinosis. The clinical variants consist of generalised confluent lichenoid eruptions (scleromyxedema) with systemic manifestations and a localised variant with discrete papular eruptions. The cases which do not fit into either of the category are termed as atypical or intermediate form. We report such a cas...

Lichen myxedematosus is a cutaneous mucinosis of idiopathic origin. According to Rongioletti’s classification, 2006, lichen myxedematosus is classified into three forms. The scleromyxedema or lichen myxedematosus sclerodermiform and generalized is a form of lichen myxedematosus characterized by numerous papules and areas of cutaneous hardening due to the deposition of mucin in association with ...

Scleromyxedema is a rare disease of unknown etiology primarily affecting the skin, characterized by generalized papular eruption, dermal fibroblast proliferation with mucin deposition, and a monoclonal gammopathy. Neurological impairment is a rare but sometimes fatal complication of scleromyxedema that should be rapidly identified to prevent significant morbidity and mortality. A 63-year-old Ca...

BACKGROUND Scleromyxedema is a rare chronic fibromucinous disorder that can have devastating clinical manifestations, including sclerosis of the skin with progressive pharyngeal and upper airway involvement, resulting in high mortality due to respiratory complications. Herein we describe a novel therapeutic approach. Because autologous hematopoietic stem cell transplantation is effective in oth...

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