Objective(s) The role of Elaeagnus angustifolia fruit as an analgesic agent in acute pain has been proved earlier. In this study, the effects of aqueous extracts of three parts of this fruit (pericarp, medulla and seed) on chronic pain were investigated in mice. Materials and Methods A partial nerve injury was made using a tight ligature around the sciatic nerve, then doses (0.5, 1, 1.5 g/kg...

Described here is a comparison of five peripheral sciatic nerve injury models in rats which all result in various degrees of neuropathic pain symptoms. They are the chronic constriction injury (CCI), the spinal nerve ligation (SNL), the partial sciatic ligation (PSL), the tibial and sural transection (TST), and the complete sciatic transection (CST) model. Behavioral testing was performed on th...

Elucidation of the mechanisms underlying neuropathic pain is expected to aid in the discovery and selection of effective therapeutic methods. Currently, microRNA (miRNA) is thought to play an important role in the development and maintenance of the nervous system. We, therefore, hypothesized that miRNAs are involved in neuropathic pain, and invest...

objective(s) the role of elaeagnus angustifolia fruit as an analgesic agent in acute pain has been proved earlier. in this study, the effects of aqueous extracts of three parts of this fruit (pericarp, medulla and seed) on chronic pain were investigated in mice. materials and methods a partial nerve injury was made using a tight ligature around the sciatic nerve, then doses (0.5, 1, 1.5 g/kg, i...

PURPOSE To validate and explore the application of a rat model of chronic constriction injury to the partial sciatic nerve in investigation of acupuncture analgesia. METHODS Chronic constriction injury of the sciatic nerve (CCI) and chronic constriction injury of the partial sciatic nerve (CCIp) models were generated by ligating either the sciatic nerve trunk or its branches in rats. Both mod...

To study the neuropathic pain mechanism, various behavioral responses of animals in to different neuropathic models were considered. Adult male Sprague-Dawley rats weighing 230-280 g were used. Anesthesia was initially induced with pentobarbital I.P. (50 mg/kg). These models included (1): chronic constriction injury (CCI) by loose ligation of the sciatic nerve (2) Spared nerve injury (SNI) by a...

Background: Clinical studies have shown that applying pulsed radiofrequency (PRF) to the neural stem could relieve neuropathic pain (NP), albeit through an unclear analgesic mechanism. And animal experiments have indicated that calcitonin gene-related peptide (CGRP) expressed in the dorsal root ganglion (DRG) is involved in generating and maintaining NP. In this case, it is uncertain whether PR...

Objective(s): To investigate the systemic and local immune status of two surgical rat models of sciatic nerve injury, a crushed sciatic nerve, and a sciatic nerve transection Materials and Methods:Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham-operation (control group), sciatic nerve crush, and sciatic nerve transaction. Sciatic nerve surgery was perfor...

The present study was undertaken to further investigate the role of glial cells in the development of the neuropathic pain-like state induced by sciatic nerve ligation in mice. At 7 days after sciatic nerve ligation, the immunoreactivities (IRs) of the specific astrocyte marker glial fibrillary acidic protein (GFAP) and the specific microglial marker OX-42, but not the specific oligodendrocyte ...