OBJECTIVE To evaluate the ability of a tissue-engineered nerve construct composed of a nerve guidance channel and neurally differentiated human adipose tissue-derived stem cells (hASCs) to enhance peripheral nerve regeneration in a rat sciatic nerve model. DESIGN A 13-mm sciatic nerve gap was bridged with silastic conduits in 64 athymic nude rats, and differentiated hASCs were implanted into ...

objective: to assess the effect of combination of pulsed electromagnetic fields (pemf) with predatory stress on transected sciatic nerve regeneration in rats.  methods: in sham- operated group (sog) the nerve was manipulated and left intact. the 10-mm rat sciatic nerve gap was created in rats. in transected group (transected) nerve stumps were sutured to adjacent muscle and in vein graft group ...

OBJECTIVE Topical cytidine-5'-diphosphocholine (CDP-choline) improves functional recovery and promotes nerve regeneration in sciatic nerve injury in rats. The aims of this study were to test whether systemic treatment with CDP-choline was effective in improving the recovery of injured sciatic nerve, and to determine whether the cytidine and/or choline moieties of CDP-choline contribute to its ...

introduction: repair of peripheral nerve injuries is an intensive area of challenge and research in modern reconstructive microsurgery. intensive research is being carried out to develop effective alternatives to the standard nerve autografting, avoiding its drawbacks. the aim of the study was to evaluate the effectiveness of a newly designed mechanical device for the reconstruction of the scia...

BACKGROUND Cytidine 5'-diphosphocholine (citicoline) has been shown to have beneficial effects in central nervous system injury as well as in motoric functional recovery after peripheral nerve injury. This study aimed to examine the effect of citicoline on prevention of neuropathic pain in a rat model of sciatic nerve crush injury. METHODS Forty experimental rats were divided into four groups...

Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...

BACKGROUND Initial studies have shown that low-energy ultrasound stimulates living tissue cells to reduce regeneration or speed up their recovery. The purpose of this study was to examine the effects of various ultrasound parameters on the speed of recovery in injured sciatic nerves. METHODS NMRI mice (n = 200) with injured left paw, caused by crushing their sciatic nerves, were randomly sele...

background: effects of platelet-derived growth factor b (pdgf-b) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model. materials and methods: forty‑five male, white wistar rats were divided into three experimental groups (n = 15), randomly: normal control group (nc), silicon group (sil), and pdgf‑b treated group (sil/pdgf). in nc group, left sciatic nerve was...

Introduction: Repair of peripheral nerve injuries is an intensive area of challenge and research in modern reconstructive microsurgery. Intensive research is being carried out to develop effective alternatives to the standard nerve autografting, avoiding its drawbacks. The aim of the study was to evaluate the effectiveness of a newly designed mechanical device for the reconstruction of the...

abstract   background : although, different studies on end-to-side nerve repair, results are controversial. the importance of this method in case is unavailability of proximal nerve. in this method, donor nerves also remain intact and without injury. in compare to other classic procedures, end-to-side repair is not much time consuming and needs less dissection. overall, the previous studies in ...