نتایج جستجو برای: scd14

تعداد نتایج: 398  

Journal: :The Journal of clinical investigation 2001
R L Kitchens P A Thompson S Viriyakosol G E O'Keefe R S Munford

CD14, a myeloid cell-surface receptor and soluble plasma protein, binds LPS and other microbial molecules and initiates the innate immune response to bacterial invasion. The blood concentration of soluble CD14 (sCD14) increases during the systemic response to infection. Although high sCD14 blood levels have correlated with increased risk of dying from severe sepsis, sCD14 can diminish cell resp...

Journal: :Infection and immunity 2002
Karine Vidal Anne Donnet-Hughes Dominique Granato

Intestinal epithelial cells (IECs) respond to lipopolysaccharide (LPS) from gram-negative bacteria in the presence of the soluble form of CD14 (sCD14), a major endotoxin receptor. Since sCD14 is also known to interact with gram-positive bacteria and their components, we looked at whether sCD14 could mediate their effects on human IECs. To this end, we examined the production of proinflammatory ...

Journal: :Respiratory Research 2008
Caroline S Sandström Natalia Novoradovskaya Corrado M Cilio Eeva Piitulainen Tomas Sveger Sabina Janciauskiene

BACKGROUND CD14, a receptor for lipopolysaccharides (LPS), is found in both a membrane-bound form (mCD14) and a soluble form (sCD14). It is suggested that sCD14 is mainly released from blood monocytes by serine protease-mediated shedding. Because alpha1-antitrypsin (AAT), an inhibitor of serine proteases, has been shown to regulate CD14 expression in human monocytes in vitro, we sought to inves...

Journal: :The Journal of Experimental Medicine 1992
E A Frey D S Miller T G Jahr A Sundan V Bazil T Espevik B B Finlay S D Wright

CD14 is a 55-kD protein found both as a glycosylphosphatidyl inositol-linked protein on the surface of mononuclear phagocytes and as a soluble protein in the blood. CD14 on the cell membrane (mCD14) has been shown to serve as a receptor for complexes of lipopolysaccharide (LPS) with LPS binding protein, but a function for soluble CD14 (sCD14) has not been described. Here we show that sCD14 enab...

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2011
Juan F Navarro-González Carmen Mora-Fernández Mercedes Muros de Fuentes Javier Donate-Correa Violeta Cazaña-Pérez Javier García-Pérez

BACKGROUND AND OBJECTIVES Hyperphosphatemia and subclinical endotoxemia are important sources of inflammation in HD. Proinflammatory cytokines are strong correlates of soluble CD14 (sCD14) concentrations, an independent predictor of mortality in this population. We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and s...

Journal: :The Journal of infectious diseases 2012
Theodoros Kelesidis Michelle A Kendall Otto O Yang Howard N Hodis Judith S Currier

BACKGROUND The relationships between soluble CD14 (sCD14), endotoxin (lipopolysaccharide [LPS]), and progression of atherosclerosis have not been defined in human immunodeficiency virus (HIV) infection. METHODS We retrospectively assessed serum sCD14 and LPS levels of 91 subjects in a prospective 3-year study of carotid artery intima-media thickness (CIMT) (AIDS Clinical Trials Group [ACTG] 5...

2015
Masayuki Sato Gaku Takahashi Shigehiro Shibata Makoto Onodera Yasushi Suzuki Yoshihiro Inoue Shigeatsu Endo Sachin Yende

We previously reported that a soluble CD14-subtype (sCD14-ST) immunochromatographic test (ICT) for plasma is more convenient than chemiluminescent enzyme immunoassay (CLEIA), but plasma separation makes bedside measurements difficult. We developed a new sCD14-ST ICT for whole blood and investigated whether quantitative determinations of sCD14-ST by ICT were useful for diagnosing sepsis and seve...

Journal: :Journal of immunology 1999
A Cauwels K Frei S Sansano C Fearns R Ulevitch W Zimmerli R Landmann

Murine experimental meningitis models induced by either Escherichia coli LPS, live Streptococcus pneumoniae, or Listeria monocytogenes were used to study the origin and potential function of soluble CD14 (sCD14) in the brain during bacterial meningitis. Whereas intracerebral infection caused only a minor and/or transient increase of sCD14 levels in the serum, dramatically elevated concentration...

2014
David F. G. Malone Karolin Falconer Ola Weiland Johan K. Sandberg

Soluble CD14 (sCD14) and IL-18 are markers and mediators of the innate immune response, and their plasma levels candidate biomarkers of HCV treatment effects and outcome. Here, we retrospectively studied sCD14 and IL-18 over the course of interferon-based treatment of HCV genotype 1 infection, with the aim to investigate the impact of direct-acting antivirals (DAAs) on the dynamics and relation...

Journal: :The Journal of biological chemistry 2002
Theresa L Gioannini DeSheng Zhang Athmane Teghanemt Jerrold P Weiss

Experiments utilizing endotoxin aggregates, lipooligosaccharides (LOS) isolated from metabolically labeled Neisseria meningitidis serotype group B, demonstrate that albumin is an essential component of lipopolysaccharide binding protein- (LBP) and sCD14-dependent 1) disaggregation of LOS and 2) LOS activation of human umbilical vein endothelial cells (HUVEC). Aggregates of LOS (LOS(agg)) with a...

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