Wound healing in adult skin, a complex process involving many cell types and processes such as epidermal, fibroblastic, and endothelial cell proliferation, cell migration, matrix synthesis, and wound contraction, almost invariably results in scar tissue formation and wound induration. Unlike in adult skin, wound healing in embryos involves repair processes that result in the essentially perfect...

Abstract Aims Ventricular tachycardia (VT) in ischaemic cardiomyopathy (ICM) originates from scar, identified as low-voltage areas with invasive high-density electroanatomic mapping (EAM). Abnormal myocardial deformation on speckle tracking strain echocardiography can non-invasively identify scar. We examined if regional and global longitudinal (GLS) localize quantify scar EAM. Methods results ...

Background In clinical practice, perfusion, viability and systolic myocardial function are fundamental to the evaluation of ischemic patients. Deformation of muscle expresses active contraction and can be represented by strain in various directions. Improvements to the “DENSE” technique, “Displacement Encoding with Stimulated Echoes”, have shown high accuracy warranting its application to clini...

Improved healing rates are obtained upon the application of composite dressings as compared to pure BC. mBC-SS2 prevents excessive wound contraction which leads hypertrophied neo-tissue formation when rBC-SS2 is used. The collagen fibers aligned along width microgroove mBC and its composites while anarchic deposited in presence rBC composites. Relatively rBC-SS2, constitutes an improved dressin...

Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a ple...

Pathological myofibroblasts are often involved in skin scarring via generating contractile force and over-expressing collagen fibers, but no compound has been found to inhibit the myofibroblasts without showing severe toxicity to surrounding physiological cells. Here we report that di-rhamnolipid, a biosurfactant secreted by Pseudomonas aeruginosa, showed potent effects on scar therapy via a un...

Adverse hypertrophic scars can form after healing of full-thickness skin wounds. Currently, reliable animal and in vitro models to identify and test novel scar reducing therapeutics are scarce. Here we describe the development and validation of a tissue-engineered human hypertrophic scar (HTscar) model based on reconstructed epidermis on a dermal matrix containing adipose derived mesenchymal st...

While skin wounds heal by scarring, wounds of oral mucosa show privileged healing with minimal scar formation. Our hypothesis was that phenotypic differences between oral and skin fibroblasts underlie these differences in healing. The aims of this study were to compare MMP-3 expression by oral and skin fibroblasts and investigate a role for MMP-3 in mediating collagen gel contraction. Oral fibr...

OBJECTIVE The prognosis of apical hypertrophic cardiomyopathy (APH) has been benign, but apical myocardial injury has prognostic importance. We studied functional, morphological and electrocardiographical abnormalities in patients with APH and with apical aneurysm and sought to find parameters that relate to apical myocardial injury. METHODS STUDY DESIGN a multicentre trans-sectional study...