PAR-3 (partitioning-defective) is a scaffold-like PDZ (postsynaptic density-95/discs large/zonula occludens-1) domain-containing protein that forms a complex with PAR-6 and atypical PKC, localizes to tight junctions, and contributes to the formation of functional tight junctions. There are several alternatively spliced isoforms of PAR-3, although their physiological significance remains unknown...

Recent studies have reported on the molecular mechanisms underlying dendritic spine (spine) dynamics. Because most of these studies investigated spine dynamics by overexpressing constitutively active or dominant-negative PSD (postsynaptic density) proteins in cultured mature neurons, the results represent the enlargement of mature spines or their return to an immature state. Here, we developed ...

Sociobiol. 32, 167–176 (1993). 4. Johnstone, R. A. Multiple displays in animal communication: ‘backup signals’ and ‘multiple messages’. Phil. Trans. R. Soc. Lond. B 351, 329–338 (1996). 5. Brooks, R. & Endler, J. A. Female guppies agree to differ: phenotypic and genetic variation in matechoice behavior and the consequences for sexual selection. Evolution 55, 1644–1655 (2001). 6. Kodric-Brown, A...

Divide-and-conquer is a well-suited programming paradigm for parallel Grid applications. Our Satin system efficiently schedules the fine-grained tasks of a divide-andconquer application across multiple clusters in a grid. To accommodate long-running applications, we present a fault-tolerance mechanism for Satin that has negligible overhead during normal execution, while minimizing the amount of...

The national library of France (BnF) is in the process of setting up a digital preservation repository, named SPAR (Système de Préservation et d’Archivage Réparti – Distributed Preservation and Archiving System). The infrastructure for the system, bought in 2005, is designed to support 1,5 petabytes of storage by 2014. The software components of the system are currently developped by Atos Origi...

Title of Document: ANALYTICAL MODELING AND EXPERIMENTAL EVALUATION OF A PASSIVELY MORPHING ORNITHOPTER WING Aimy Wissa, Doctor of Philosophy, 2014 Directed By: Langley Distinguished Professor, James E. Hubbard, Jr., Department of Aerospace Engineering Ornithopters or flapping wing Unmanned Aerial Vehicles (UAVs) have potential applications in both civil and military sectors. Amongst all categor...

In recent years, embedded systems with multiple processors have become increasingly important. These systems often consistof a general-purpose processor and one, oreven several, digital signal processors (DSPs). For portability, flexibility, and robustness it is often useful to regard such a cluster as a single, parallel, system. Since such a system contains several types of processors, it is s...

Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called injectisome. Its small hydrophobic export apparatus components SpaP and SpaR were shown to nucleate assembl...

It should be kept in mind that the key component of all the polarimeters and saccharimeters mentioned in this account is a pair of Nicol prisms. These were always made from crystals of Iceland spar (optical calcite). The crystals were mostly obtained from a single quarry in East Iceland from before 1800 up to the early 1920s, and to a minor extent from another quarry in Southeast Iceland from 1...

This paper introduces a novel augmentation to the Mohlich and Nielsen’s heuristic usability evaluation methodology. The SPAR-H human reliability analysis method was developed for categorizing human performance in nuclear power plants. Despite the specialized use of SPAR-H for safety critical scenarios, the method also holds promise for use in commercial off-the-shelf software usability evaluati...