ackground: Agonists at the N-methyl-D-aspartate (NMDA)-glycine site (D-serine, glycine, D-alanine and D-cycloserine) and glycine ransporter-1 (GlyT-1) inhibitor (N-methylglycine, or called sarcosine) both improve the symptoms of stable chronic schizophrenia atients receiving concurrent antipsychotics. Previous studies, however, found no advantage of D-serine, glycine, or D-cycloserine dded to c...

Glutamate is the main excitatory neurotransmitter in the central nervous system. Dysfunction of the glutamatergic system plays an important role in the pathogenesis of schizophrenia. Therefore, glutamatergic agents such as N-methyl-D-aspartate receptor co-agonists (ie, glycine, D-cycloserine) and glycine transporter type 1 inhibitors (eg, sarcosine) are studied for their efficacy in amelioratin...

Sarcosine is currently one of the most discussed markers of prostate cancer. It is involved in amino acid metabolism and methylation processes that occur during the progression of prostate cancer. In this study, we monitored the effect of the addition of sarcosine (0; 10; 250; 500; 1,000 and 1,500 µM) in a time-dependent manner (0-72 h) on the PC-3 prostate cancer cell line. For the assessment ...

Sarcosine oxidase (EC 1.5.3.1; sarcosine:oxygen oxidoreductase [demethylating]) is a flavoprotein that catalyses the oxidative demethylation of sarcosine to yield glycine, formaldehydethe, and hydrogen peroxide. This enzyme is involved in the bacterial metabolism of creatinine with the related enzymes, creatininase and creatinase. It is industrially important and is used with creatininase and c...

Despite the obvious significance, the aqueous interactions of peptides remain incompletely understood. Their synthetic analogues called peptoids (poly-N-substituted glycines) have recently emerged as a promising biomimetic material, particularly due to their robust secondary structure and resistance to denaturation. We describe comparative near-edge X-ray absorption fine structure spectroscopy ...

The glutamatergic system is a key point in pathogenesis of schizophrenia. Sarcosine (N-methylglycine) is an exogenous amino acid that acts as a glycine transporter inhibitor. It modulates glutamatergic transmission by increasing glycine concentration around NMDA (N-methyl-d-aspartate) receptors. In patients with schizophrenia, the function of the glutamatergic system in the prefrontal cortex is...

A supramolecular approach for the specific detection of sarcosine, recently linked to the occurrence of aggressive prostate cancer forms, has been developed. A hybrid active surface was prepared by the covalent anchoring on Si substrates of a tetraphosphonate cavitand as supramolecular receptor and it was proven able to recognize sarcosine from its nonmethylated precursor, glycine, in water and...

It has been established that the enzyme, sarcosine oxidase, found in the mitochondria of rat liver and elsewhere (I), catalyzes the following over-all reaction (2, 3) : sarcosine + $02 = glycine + serine + HCHO. The cofactor requirements of this reaction have not been established, although Mackenzie (1) has mentioned unpublished results which seemed to indicate that a folic acid deficiency in r...

DOI: 10.1002/elps.202100218 The front cover picture shows an MXene-based amperometric biosensor for sensitive detection of sarcosine, recently identified as alternative biomarker prostate cancer. Ti3C2Tx MXene nanosheets decorated with Pt-Pd bimetallic NPs exhibit enhanced electrocatalytic activity and stability during the electrochemical process, making them suitable development. In this work,...

Both crystallization and cryoprotection are often bottlenecks for high-resolution X-ray structure determination of macromolecules. Methylamine osmolytes are known stabilizers of protein structure. One such osmolyte, trimethylamine N-oxide (TMAO), has seen occasional use as an additive to improve macromolecular crystal quality and has recently been shown to be an effective cryoprotective agent f...