To the Editor—We read with great interest Kuberski and Yourison’s hypothesis that Coccidioides spp. and other dimorphic fungi may be the precipitants of sarcoidosis in a proportion of cases [1]. We would like to suggest additional ways to test this hypothesis, as well as suggesting that Cryptococcus spp. be included in the list of fungi considered possible precipitants. A single-center study of...

Pulmonary lesions, with sarcoid-like granulomas exhibiting noncaseous necrosis, with associated granulomatous arteritis fulfil the diagnostic criteria of necrotizing sarcoid granulomatosis (NSG). We report the case of a woman who presented with recurrent headaches, transient right hemipareses and left-sided ophthalmoplegia. An excised left retro-orbital lesion demonstrated sarcoid like changes,...

The equine sarcoid, a locally aggressive, fibroblastic skin tumour, is the most common dermatological neoplasm reported in horses; there is no consistently effective therapy. It is widely accepted that bovine papillomavirus (BPV) types 1 and 2 are associated with the pathogenesis of sarcoid disease. Most sarcoids appear to contain detectable viral DNA and RNA and are also known to express the B...

Described herein are clinical and morphologic findings in 2 patients who underwent heart transplantation because of severe heart failure resulting from cardiac sarcoidosis. Although the explanted hearts in each patient had characteristic gross changes of cardiac sarcoidosis, one patient who had been treated with prednisone, had no residual sarcoid granulomas in the myocardium, whereas the other...

The presence of granuloma in a biopsy specimen is not specific to sarcoidosis, and sarcoid-like granulomatous reaction can be found in chronic inflammatory, infectious and neoplastic diseases. Sarcoid reaction may occur in lymph nodes draining an area housing a malignant tumor, in the tumor itself and in nonregional tissues. Overall, sarcoid reaction occurs in 4.4% of cancers, 13.8% of patients...