cystadenoma is a rare benign salivary gland tumor that chiefly originates in the minor salivary glands as a cystic growth with papillary projections into the cystic lumen without the lymphoid element. it is further classified into two histopathological variants that have been recognized by world health organization as the papillary and the mucinous forms of cystadenoma. clinically, it is diffic...

introduction: natural killer (nk) cells, of which cd56 is a specific marker, play an important role in host defense against tumors. cancer stem cells, of which aldehyde dehydrogenase isoform 1 (aldh1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. we aimed to evaluate the expression of aldh1 and cd56 in common salivary g...

Transcription factors drive organogenesis, from the initiation of cell fate decisions to the maintenance and implementation of these decisions. The Drosophila embryonic salivary gland provides an excellent platform for unraveling the underlying transcriptional networks of organ development because Drosophila is relatively unencumbered by significant genetic redundancy. The highly conserved FoxA...

Salivary glands are exocrine that secrete saliva, which plays an important role in the maintenance of oral health. Few reports exist on contralateral salivary gland is not directly affected when one by sialolithiasis, radiation therapy, or a tumor. In present study, we investigated changes submandibular mice following excision unilateral gland. Outcomes this study showed and sublingual resectio...

introduction sialolithiasis is the most common disease of salivary glands. sialography is particularly important for the assessment of the outflow tract and in diagnosing obstructive salivary gland lesions including calculi. case presentation we report on a 38-year-old female with sialolithiasis whom had wharton’s duct perforation, complicating the sialography. she was treated conservatively wi...

OBJECTIVE The objective of this study was to determine the effect of epithelial barrier disruption, caused by deficiency of the membrane-anchored serine protease, matriptase, on salivary gland function and the induction of autoimmunity in an animal model. METHODS Embryonic and acute ablation of matriptase expression in the salivary glands of mice was induced, leading to decreased epithelial b...

sialolithiasis is a common disease of the major salivary glands, characterized by the obstruction of a salivary gland or its excretory duct due to the formation of calcareous concretions. sialoliths usually measure from 1 mm to <10 mm. they rarely measure more than 15 mm, and infrequently giant salivary gland calculi >15 mm have been reported in the literature. the submandibular gland and its d...

OBJECTIVE The commonly associated aetiology of salivary gland inflammation and salivary hypofunction has led to the widely held belief that inflammation causes salivary gland hypofunction. Indeed, our own recent study seemed to support this contention. Here, we tested the hypothesis that, in an acute duct ligation model, eliminating inflammation the submandibular gland would recover normal func...

Head and neck cancer is the fifth most common malignancy and accounts for 3% of all new cancer cases each year. Despite relatively high survival rates, the quality of life of these patients is severely compromised because of radiation-induced impairment of salivary gland function and consequential xerostomia (dry mouth syndrome). In this study, a clinically applicable method for the restoration...