Pili are critical in host recognition, colonization and biofilm formation during bacterial infection. Here, we report the crystal structures of SafD-dsc and SafD-SafA-SafA (SafDAA-dsc) in Saf pili. Cell adherence assays show that SafD and SafA are both required for host recognition, suggesting a poly-adhesive mechanism for Saf pili. Moreover, the SafDAA-dsc structure, as well as SAXS characteri...

Paul Robeson Park in Los Angeles County was often the designated location for Eid al-Fitr, the obligatory group prayer and celebration following Ramadan, the Islamic month of fasting. Families, predominantly African American, would begin arriving around 7:00 am dressed in their best Eid clothing. Well before the crowd began to trickle in, plastic tarps would be positioned in straight rows so th...

Minimal research exists for non-chromatographic separations of rare-earth metallofullerenes containing di-metallic (M2), di-metallic carbide (M2C2), and tri-metallic nitride (M3N) clusters trapped inside fullerene cages. Herein, we demonstrate a non-HPLC method (i.e., SAFA, Stir and Filter Approach) for purifying Er3N@Ih-C80, a rare-earth, metallic nitride clusterfullerene. We describe a strate...

Footprinting is a powerful and widely used tool for characterizing the structure, thermodynamics, and kinetics of nucleic acid folding and ligand binding reactions. However, quantitative analysis of the gel images produced by footprinting experiments is tedious and time-consuming, due to the absence of informatics tools specifically designed for footprinting analysis. We have developed SAFA, a ...

Dietary fats have important effects on the risk of cardiovascular disease (CVD). Abundant evidence shows that partial replacement of saturated fatty acids (SAFA) with unsaturated fatty acids improves the blood lipid and lipoprotein profile and reduces the risk of coronary heart disease (CHD). Low-fat diets high in refined carbohydrates and sugar are not effective. Very long-chain polyunsaturate...

There is increasing evidence that dietary saturated fatty acids (SAFA) have not only an indirect atherogenic effect due to increasing LDL-cholesterol concentration but also a direct effect by activating the inflammation process. This review summarizes several recent publications in this field. The effect of SAFA on the inflammation process mediated by Toll-like receptor 4/NF-kappaB pathway has ...

Detection of deep and hidden mineralization using the surface geochemical data is a challenging subject in the mineral exploration. In this work, a novel scenario based on the spectrum–area fractal analysis (SAFA) and the principal component analysis (PCA) has been applied to distinguish and delineate the blind and deep Mo anomaly in the Dalli Cu–Au porphyry mineralization area. The Dalli miner...

İhvan-ı Safa’nın varlık anlayışını irdelediğimiz bu makalede araştırmanın konusu Risalelerde genişçe yer alan varlığın oluş halini belirlemeye çalışmaktır. İhvan konusunu Risalelerin tamamında dağınık halde ele alırken, problemini özel bir başlıkla, “Oluş ve Bozuluş” adı altında daha derli toplu incelemiştir. Safa felsefesinde teorisini merkeze alarak oluşum süreçlerini düşünce temellendirmeler...