Footprinting is a powerful and widely used tool for characterizing the structure, thermodynamics, and kinetics of nucleic acid folding and ligand binding reactions. However, quantitative analysis of the gel images produced by footprinting experiments is tedious and time-consuming, due to the absence of informatics tools specifically designed for footprinting analysis. We have developed SAFA, a ...

Dietary fats have important effects on the risk of cardiovascular disease (CVD). Abundant evidence shows that partial replacement of saturated fatty acids (SAFA) with unsaturated fatty acids improves the blood lipid and lipoprotein profile and reduces the risk of coronary heart disease (CHD). Low-fat diets high in refined carbohydrates and sugar are not effective. Very long-chain polyunsaturate...

There is increasing evidence that dietary saturated fatty acids (SAFA) have not only an indirect atherogenic effect due to increasing LDL-cholesterol concentration but also a direct effect by activating the inflammation process. This review summarizes several recent publications in this field. The effect of SAFA on the inflammation process mediated by Toll-like receptor 4/NF-kappaB pathway has ...

İhvan-ı Safa’nın varlık anlayışını irdelediğimiz bu makalede araştırmanın konusu Risalelerde genişçe yer alan varlığın oluş halini belirlemeye çalışmaktır. İhvan konusunu Risalelerin tamamında dağınık halde ele alırken, problemini özel bir başlıkla, “Oluş ve Bozuluş” adı altında daha derli toplu incelemiştir. Safa felsefesinde teorisini merkeze alarak oluşum süreçlerini düşünce temellendirmeler...

Background Psychological factors influence quality of life, disease perception, engagement and adherence to treatment in patients with Juvenile Idiopathic Arthritis (JIA). While anxiety and/or depression have been often documented JIA, alexithymia has seldom investigated. Objectives 1.To investigate the frequency psychic symptoms JIA at a single tertiary care center, including depressive, alexi...

BACKGROUND Canine ventral atlantoaxial (AA) stabilization is most commonly performed in very small dogs and is technically challenging due to extremely narrow bone corridors. Multiple implantation sites have been suggested but detailed anatomical studies investigating these sites are lacking and therefore current surgical guidelines are based upon approximate anatomical landmarks. In order to s...