نتایج جستجو برای: s1p receptor

تعداد نتایج: 591328  

Journal: :Cells 2023

Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various cells, including keratinocytes, dendritic T lymphocytes, neutrophils. The treatments for psoriasis range from topical to systemic therapies, but they only alleviate symptoms do not provide fundamental cure. Moreover, have disadvantage of suppressing entire body’...

Journal: :Journal of Investigative Dermatology 2023

Cutaneous squamous cell carcinoma (cSCC) is a common cancer, caused by mutagenesis from excess ultraviolet radiation (UVR) or other types of oxidative stress. These stressors also upregulate production key innate immune element, cathelicidin antimicrobial peptide (CAMP), via endoplasmic reticulum (ER) stress-initiated, sphingosine-1-phosphate (S1P) signaling. While CAMP has beneficial activitie...

Journal: :International journal of oncology 2012
Andrew Hsu Wenliang Zhang Jen-Fu Lee Jin An Prasanna Ekambaram Jingjing Liu Kenneth V Honn Carolyn M Klinge Menq-Jer Lee

Sphingosine-1-phosphate (S1P) regulates a wide array of biological functions. However, the role of S1P signaling in tumorigenesis remains to be elucidated. In this study, we show that S1P receptor subtype 3 (S1P₃) is markedly up-regulated in a subset of lung adenocarcinoma cells compared to normal lung epithelial cells. Specific knockdown of S1P₃ receptors inhibits proliferation and anchorage-i...

Journal: :American journal of respiratory cell and molecular biology 2006
Matiur Rahaman Richard W Costello Kristen E Belmonte Samir S Gendy Marie-Thérèse Walsh

The phospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via transmembrane receptors S1P 1-5 and LPA 1-3, respectively. Both have been implicated in inflammatory responses. S1P and LPA receptor profiles on neutrophils of patients with pneumonia compared with healthy subjects were determined by PCR and Western blotting. Chemotaxis studies were performed to assess funct...

2011
Stuart M. Cahalan Pedro J. Gonzalez-Cabrera Gor Sarkisyan Nhan Nguyen Marie-Therese Schaeffer Liming Huang Adam Yeager Bryan Clemons Fiona Scott Hugh Rosen

Sphingosine 1-phosphate receptor 1 (S1P(1)) is critical for lymphocyte recirculation and is a clinical target for treatment of multiple sclerosis. By generating a short-duration S1P(1) agonist and mice in which fluorescently tagged S1P(1) replaces wild-type receptor, we elucidate physiological and agonist-perturbed changes in expression of S1P(1) at a subcellular level in vivo. We demonstrate d...

Journal: :Molecular pharmacology 2001
D J Fischer N Nusser T Virag K Yokoyama Wang Da D L Baker D Bautista A L Parrill G Tigyi

Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are members of the phospholipid growth factor family. A major limitation in the field to date has been a lack of receptor subtype-specific agonists and antagonists. Here, we report that dioctylglycerol pyrophosphate and dioctylphosphatidic acid are selective antagonists of the LPA(1) and LPA(3) receptors, but prefer LPA(3) by an orde...

Journal: :American journal of physiology. Heart and circulatory physiology 2007
Jianqing Zhang Norman Honbo Edward J Goetzl Kanu Chatterjee Joel S Karliner Mary O Gray

Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that serves as a key regulator of cellular differentiation and survival. Immune stimuli increase S1P synthesis and secretion by mast cells and platelets, implicating this molecule in tissue responses to injury and inflammation. Binding of S1P to G(i) protein-coupled receptors activates phosphatidylinositol 3-kinase and Akt ...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2006
Wenhui Hu Sunila Mahavadi Jiean Huang Fang Li Karnam S Murthy

Sphingosine-1-phosphate (S1P) induces an initial Ca(2+)-dependent contraction followed by a sustained Ca(2+)-independent, RhoA-mediated contraction in rabbit gastric smooth muscle cells. The cells coexpress S1P(1) and S1P(2) receptors, but the signaling pathways initiated by each receptor type and the involvement of one or both receptors in contraction are not known. Lentiviral vectors encoding...

2011
Salvatore Salomone Christian Waeber

Receptors for sphingosine-1-phosphate (S1P) have been identified only recently. Their medicinal chemistry is therefore still in its infancy, and few selective agonists or antagonists are available. Furthermore, the selectivity of S1P receptor agonists or antagonists is not well established. JTE-013 and BML-241 (also known as CAY10444), used extensively as specific S1P(2) and S1P(3) receptors an...

Journal: :Circulation research 2004
Tatsuo Tanimoto Andreea O Lungu Bradford C Berk

Sphingosine 1-phosphate (S1P) is a bioactive lipid generated during vascular injury that regulates cell growth, differentiation, survival, and motility via endothelial differentiation gene (EDG) family G protein-coupled receptors. Although several G protein-coupled receptor ligands transactivate receptor tyrosine kinases, such as the epidermal growth factor receptor (EGFR), S1P-stimulated recep...

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