Inhibition of mTOR signaling by rapamycin has been shown to activate extracellular signal-regulated kinase 1 or 2 (ERK1/2) and Akt in various types of cancer cells, which contributes to rapamycin resistance. However, the downstream effect of rapamycin-activated ERKs and Akt on survival or death substrate(s) remains unclear. We discovered that treatment of human lung cancer cells with rapamycin ...

Preface —M. C. Latham, H. Mehansho, and F. S. Solon............................................................................... S65 Overview: Hidden hunger and the role of public-private partnership —M. C. Latham .......................... S67 Combating hidden hunger: The role of international agencies —N. Dalmiya and W. Schultink ............. S69 Vitamin A deficiency disorders in children ...

Inhibition of mTOR signaling by rapamycin has been shown to activate extracellular signal-regulated kinase 1 or 2 (ERK1/2) and Akt in various types of cancer cells, which contributes to rapamycin resistance. However, the downstream effect of rapamycin-activated ERKs and Akt on survival or death substrate(s) remains unclear. We discovered that treatment of human lung cancer cells with rapamycin ...

The transcription factor nuclear factor of activated T cell 5 (NFAT5) is activated by the stress of hypertonicity (e.g., high NaCl). Increased expression of NFAT5 target genes causes accumulation of protective organic osmolytes and heat shock proteins. Under normotonic conditions (∼300 mosmol/kgH(2)O), NFAT5 is distributed between the nucleus and cytoplasm, hypertonicity causes it to translocat...

Novel sites of expression of the bHLH gene NSCL1 in the developing nervous system S103 Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea S111 Widespread expression of an extended peptide sequence of GATA-6 during murine embryogenesis and non-equivalence of RNA and protein expression domains S121 F. Bajanca, S. Thorsteinsdóttir (Portugal) Integrin expressi...

Alarming trends in the resurgence of vector-borne diseases are anticipated to continue unless more effective action is taken to address the variety of underlying causes. Social factors, anthropogenic environmental modifications and/or ecological changes appear to be the primary drivers. The ecological dimension of vector-borne disease research and management is a pervasive element because this ...

The Healthy Cities and Agenda 21 programs improve living and health conditions and affect social and economic determinants of health. The Millennium Development Goals (MDG) indicators can be used to assess the impact of social agendas. A data search was carried out for the period 1997 to 2006 to obtain 48 indicators proposed by the United Nations and a further 74 proposed by the technical group...

View Large Image Figure ViewerDownload Hi-res image Download (PPT)View (PPT) Research is limited regarding the prevalence of drug-induced movement disorders in residents long-term care (LTC) facilities. By contrast, there extensive literature documenting that this population typically at a higher risk for disorders: both median age LTC and increased use pharmacological interventions contribute ...

The enforcement of alcohol laws prohibiting underage drinking and over-service practices has the potential to substantially reduce alcohol-related problems in the United States (US). Alcohol is related to violent and property crime, intentional and unintentional injuries, and lost productivity. In particular, alcohol is involved in 40% of US traffic fatalities and studies show that a substantia...