transplantation of CD34+ cord blood stem cells into newborn and adult NOD/SCID mice induce differential organ engraftment. Tissue Cell 2012;44:80-6. 7. Navarro-Montero O, Romero-Moya D, Montes R, et al. Intrahepatic transplantation of cord blood CD34+ cells into newborn NOD/SCID-IL2Rγ(null) mice allows efficient multi-organ and multi-lineage hematopoietic engraftment without accessory cells. Cl...

شبیه­سازی پیش از انجام درمان، یک روش موثر برای پیش­بینی آسیب حرارتی ایجاد شده در بافت است و امکان انتخاب بهترین پارامترهای ورودی را فراهم می­کند. در این مقاله، دو تکنیک درمانی مورد استفاده در درمان فیبروادنومای پستان، شامل روش درمان حرارتی با لیزر (litt) ودرمان حرارتی با امواج رادیو فرکانسی (rfa) به صورت عددی شبیه­سازی شده است. هر دو روش بر اساس مرگ بافتی برگشت ناپذیرناشی از تولید حرارت در بافت...

In March 2004, the recommendations of the American Association of Physicists in Medicine sAAPMd on the interstitial brachytherapy dosimetry using I and Pd were reported in Medical Physics fTG-43 Update: Rivard et al., 31, 633–674 s2004dg. These recommendations include some minor changes in the dose-calculation formalism and a major update of the dosimetry parameters for eight widely used inters...

Arylamine N-acetyltransferases (NATs) are phase II xenobiotic metabolism enzymes that catalyze the detoxification of arylamines by N-acetylation and the bioactivation of N-arylhydroxylamines by O-acetylation. Endogenous and recombinant mammalian NATs with high specific activities are difficult to obtain in substantial quantities and in a state of homogeneity. This paper describes the overexpres...

The last decade has seen the molecular chaperone heat shock protein 90 (HSP90) emerge as an exciting target for cancer therapy. This is because HSP90 is involved in maintaining the conformation, stability, activity and cellular localisation of several key oncogenic client proteins. These include, amongst others, ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1a, survivi...

The Authors regret that in the original abstract, Dr. Christie Orschell was listed as second author which incorrect. correct Author line is shown above. 3161 – CELLULAR AND MOLECULAR EFFECTS OF DMPGE₂ RADIOMITIGATION IN MOUSE HUMAN BONE MARROW CELLS VIVO USING C57BL/6 HUMANIZED NSG MODELS ACUTE RADIATION SYNDROMEExperimental HematologyVol. 111PreviewThe hematopoietic system highly sensitive to ...

Immunological memory is clearly an important topic in any consideration of the interaction between host and parasite, both at the individual and at the population level. However, whether such immunity is maintained via constant exposure to infection via long-lived clones of lymphocytes that are able to recognize specific antigens and maintain antibody production in the absence of repeated expos...

The phenomenon of antibiotic resistance is of practical importance and theoretical interest. However, the link between antibiotic consumption and prevalence of resistance to a given drug has been difficult to establish for a variety of reasons. As a foundation for further studies by simulation, experiment and observation, we develop a probabilistic cellular automata model for the transmission d...

Cognitive changes related to cancer and its treatment have been intensely studied, and neuroimaging has begun to demonstrate brain correlates. In the first prospective longitudinal neuroimaging study of breast cancer (BC) patients we recently reported decreased gray matter density one month after chemotherapy completion, particularly in frontal regions. These findings helped confirm a neural ba...