BACKGROUND Salmonella enterica Typhimurium (S. Typhimurium) is the most common cause of bovine salmonellosis in Japan and where it is also cause of salmonellosis in wild birds. In 2008, a postpartum cow at a dairy farm developed diarrhea caused by S. Typhimurium. The herd was extensively surveilled for Salmonella sp. and we characterized bacterial isolates from this and other cows to determine ...

Swiss white mice immunized with acetone-killed vaccines prepared from strains of Salmonella typhosa, S. typhimurium, and mouse-virulent S. typhimurium hybrids which had acquired, by conjugal genetic transfer, the S. typhosa antigens 9, Vi, and d were challenged with the S. typhimurium hybrids and with the S. typhimurium parent strain. The results of these experiments suggested that the Salmonel...

Blache and colleagues (1) state "Although previous studies in mice have observedmodest tumor control with administration of attenuated Salmonella typhimurium (S. typhimurium) alone, it has proven to be less effective in more aggressive tumor models. Moreover, in clinical trials using the S. typhimurium strain VNP20009 for treatment of metastatic melanoma, minimal tumor S. typhimurium colonizati...

We evaluated the protective efficacy of 94-kb virulence plasmid-cured, and phoP- or aroA-deficient strains of Salmonella enterica serovar Typhimurium (ΔphoP or ΔaroA S. Typhimurium) as oral vaccine candidates in BALB/c mice. Two weeks after the completion of 3 oral immunizations with 1 × 10(8) colony-forming units (CFU) of virulence plasmid-cured, and ΔphoP or ΔaroA S. Typhimurium at 10-day int...

Salmonella typhi, the etiologic agent of typhoid fever, is adapted to the human host and unable to infect nonprimate species. The genetic basis for host specificity in S. typhi is unknown. The avirulence of S. typhi in animal hosts may result from a lack of genes present in the broad-host-range pathogen Salmonella typhimurium. Genomic subtractive hybridization was successfully employed to isola...

S. typhimurium S. enteritidis S. Kentucky chicken meat MultiplexPCR The present study was conducted for identification of molecular characterization of Salmonella enterica isolated from chicken meat by using multiplex-PCR isolated from 200 samples of fresh chicken meat and 100 samples of ready to eat chicken meat. Samples were assessed by performing the pre-enrichment and enrichment culture, bi...

During apical colonization by Salmonella typhimurium, intestinal epithelial cells orchestrate a proinflammatory response that involves secretion of chemoattractants, predominantly interleukin-8, which coordinate neutrophil trans-epithelial migration at the site of infection. This host-pathogen interaction requires several S. typhimurium genes. To identify novel genes that participate in this pa...

salmonella enterica serovar typhimurium and s.enterica serovar enteritidis are the most frequently isolated serovars from food-borne diseases throughout the world. according to their antigenic profiles, salmonella shows different disease syndromes and host specificities. it is necessary and important to discriminate salmonella serovars from each other in order to ensure that each pathogen and i...

Salmonella enterica serovar Typhimurium and S.enterica serovar Enteritidis are the most frequently isolated serovars from food-borne diseases throughout the world. According to their antigenic profiles, salmonella shows different disease syndromes and host specificities. It is necessary and important to discriminate salmonella serovars from each other in order to ensure that each pathogen and i...

A mouse-virulent Salmonella typhimurium hybrid (H42), which expresses the Salmonella typhi Vi antigen in addition to S. typhi O antigens 9 and 12, and a mouse-virulent S. typhimurium hybrid (H1), which expresses only the 9 and 12 antigens of S. typhi, were compared in their behavior as challenge organisms in a system developed to assay the protective capabilities of typhoid vaccines. Swiss-Webs...