an efficient synthesis of some novel coumarin derivatives via 1, 4- michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (csa) under solvent free conditions is described. the corresponding michael addition products were obtained in good to excellent yield. the synthesized compounds were screened for their antibacterial activity against e. coli, s. aureus and an...

in this research, nanoporous silica (sba-15) was physically functionalized using2-(2-nitrobenzylideneamino) guanidine compound. this functionalized sba-15 was utilized as a new sorbentfor separation and preconcentration of some lanthanide ions. inductively coupled plasma optical emissionspectrometry (icp-oes) was used as a detection technique. the preconcentration factor of the method is 100and...

results aβ (1-42) stimulated the production of the proinflammatory cytokines il6, il1β, tnfα, and il18 in both the primary microglia cell culture and the b92 cell line. both the raav-il4 construct and the ril-4 protein were found to inhibit production of the most important aβ (1-42)-induced proinflammatory cytokine mrnas in the two types of cells with different patterns. conclusions it seems th...

a m i t r a z, a n i ns e c t i c i d e /a ca ri c i de of the f o r m a m i d i n e p e st i c i d e s group, is a ? 2 a d r e n e r g i c ag on i st a nd of t he a m i d i ne c h e m i ca l f a m il y generally us e d to c o n t r ol animal e c top a r a s i t e s. poisoning due to am i t r a z i s r a r e and characterized by c e nt r a l n e r v ous s y st e m a nd r e sp ir a to r y d e p ...

the present study aimed to evaluate the protective effect of gallic acid on gastric mucosal lesions caused by ischemia-reperfusion (i/r) injury in rat. forty male rats were randomly divided into sham, control (i/r injury) and three gallic acid-pretreated groups. to induce i/r lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 6 hr. pretreat...

purpose:     methods:     results:     conclusion:

objective(s): although low-dose radiotherapy (rt) that involves low collateral damage is more suitable for hepatocellular carcinoma (hcc) than traditional high-dose rt, but to achieve satisfactory therapeutic effect with low-dose rt, it is necessary to sensitize hcc cells to irradiation. this study was aimed to determine whether radiosensitivity of hcc cells can be enhanced using mir-26b by tar...

objective(s):one of the major challenges in the field of vaccine design is choosing immunogenic antigens which can induce a proper immune response against complex targets like malignant cells or recondite diseases caused by protozoan parasites such as leishmaniasis. the aim of this study was to find a way to construct artificial liposome-based cells containing fragments of target’s cell membran...

background: the herbicide 2, 4-dichlorophenoxyacetic acid (2, 4-d) can cause moderate to lethal poisoning. although urine alkalization has been recommended as the main treatment, hemodialysis (hd) may be more effective in severe cases. case: on 24th june 2014, a 53- year-old man ingested a high amount of 40% 2, 4-d. he suffered from mouth and epigastric burning sensation, vomiting and nausea. h...