BACKGROUND Cathepsin S (Cat S) is overexpressed in human atherosclerotic and aneurysmal tissues and may contributes to degradation of extracellular matrix, especially elastin, in inflammatory diseases. We aimed to define the role of Cat S in cardiac inflammation and fibrosis induced by angiotensin II (Ang II) in mice. METHODS AND RESULTS Cat S-knockout (Cat S(-/-)) and littermate wild-type (W...

Melittin, a significant constituent of Apis mellifera (honeybee) venom, is a water-soluble toxic peptide that has traditionally been used as an antitumor agent. However, the underlying mechanisms by which it inhibits tumor cell growth and angiogenesis remain to be elucidated. In the present study, screening for increased cathepsin S (Cat S) expression levels was performed in MHCC97-H cells and ...

Because presentation of acetylcholine receptor (AChR) peptides to T cells is critical to the development of myasthenia gravis, we examined the role of cathepsin S (Cat S) in experimental autoimmune myasthenia gravis (EAMG) induced by AChR immunization. Compared with wild type, Cat S null mice were markedly resistant to the development of EAMG, and showed reduced T and B cell responses to AChR. ...

Let $S$ be a finite subset of compact connected Riemann surface $X$ genus $g \geq 2$. $\cat{M}_{lc}(n,d)$ denote the moduli space pairs $(E,D)$, where $E$ is holomorphic vector bundle over and $D$ logarithmic connection on singular $S$, with fixed residues in centre $\mathfrak{gl}(n,\C)$, $n$ $d$ are mutually corpime. $L$ line $D_L$ $S$. $\cat{M}'_{lc}(n,d)$ $\cat{M}_{lc}(n,L)$ spaces parametri...

BACKGROUND Protein expression during prostate tumour progression in transgenic TRAMP mice was studied, with the aim of identifying proteins associated with tumour progression and castration resistant tumour growth. MATERIALS AND METHODS Protein expression was compared between normal mouse prostate, primary TRAMP tumours and peripheral metastases in long-term castrated TRAMP mice using 2-dimen...

Objectives: The purpose of this study was to investigate the Effectiveness of group Coping Skills training on reducing stress of mothers with mentally retarded childrenchr('39')s. Methods: The research method was quasi experimental with pre-test and post-test design with a control group. Population of the study was all of the mothers of mentally retarded childrenchr('39')s that referred to w...

Objectives: The present study aimed to determine the effectiveness of cognitive-behavioral therapy on internalizing problems of children with externalizing disorders Methods: It was an experimental study with a pre-test/post-test control group design. Among the students of elementary schools of Tehran City, Iran, 90 boys were selected based on the motherschr('39') report and the Child Behavior...