A. " TSG loss " model in human tumors would imply functional of physical elimination of both tumor suppressor alleles. Therefore deletion would be effective if it would eliminate one allele of the gene leading to LOH in majority of tumors. B. In aneuploid human tumors the " Mandatory chromosomal segment copy number " model considers that a tumor suppressor gene copy number gain having chance to...

By mentation I mean the totality of the conscious and subconscious adaptive functionings of a living organism. Bio-psychology is that department of the science of mentation which studies organic structures and their environments in order to determine the relations which exist between these and the mentations which accompany them. It studies such structures and environments which nature provides...

During maturation of spermatids to motile spermatozoa in Caenorhabditis elegans, large vesicles called membranous organelles (MOs) fuse with the spermatid plasma membrane. Mutations in the gene fer-1 cause abnormal spermatozoa in which the MOs do not fuse, although they abut the plasma membrane normally. Here we describe the fer-1 gene, which we found to be approximately 8.6 kb in length and to...

P olarized cell growth is important for morphogenesis and function of specialized cell types in eukaryotes. Typical tip-growing cells in plants are root hairs and pollen tubes (Fig. 1). A root hair is a highly polarized tubular structure emerging from a special type of cell on the root surface, from which water and nutrients are absorbed and supplied to the plant body (Fig. 1A). A root hair als...

This review focuses on facial emotion recognition (FER) in individuals with attention- deficit/hyperactivity disorder (ADHD). Behavioral studies of FER in ADHD have resulted in inconsistent findings. Here, we discuss the factors that vary across studies and the way that they influence FER processes in ADHD. Across reviewed studies, fear was the most deficient facial expression to be recognized....

Quinacrine, a drug with antimalarial and anticancer activities that inhibits NF-κB and activates p53, has progressed into phase II clinical trials in cancer. To further elucidate its mechanism of action and identify pathways of drug resistance, we used an unbiased method for validation-based insertional mutagenesis to isolate a quinacrine-resistant cell line in which an inserted CMV promoter dr...

OBJECTIVES To examine the association between the fractional esterification rate of cholesterol (C) in low density lipoprotein- and very low density lipoprotein-depleted plasma (FER(HDL)) and coronary artery disease (CAD) and the influence of serum HDL-C levels. BACKGROUND The function of HDL in reverse cholesterol transport is involved in the antiatherogenic action of HDL, and FER(HDL) is a ...