Psychosocial stress is associated with altered immunity, anxiety and depression. Previously we showed that repeated social defeat (RSD) promoted microglia activation and social avoidance behavior that persisted for 24days after cessation of RSD. The aim of the present study was to determine if imipramine (a tricyclic antidepressant) would reverse RSD-inducedsocial avoidance and ameliorate neuro...

In 23 patients with reflex sympathetic dystrophy (RSD) of the hand, scintigraphy with indium-111 labeled human non-specific polyclonal immunoglobulin G (In-111-IgG) was performed to investigate whether inflammatory characteristics are present in RSD. Both blood flow and accumulation over 48 h were assessed. Nineteen patients had increased flow to the affected hand, and 3 had decreased flow. One...

Many aspects of bilateral presentation or recurrence of reflex sympathetic dystrophy (RSD) are unknown. For this reason 1183 consecutive patients with RSD were analyzed. In 10 patients RSD started in symmetrical limbs. In 34 patients RSD recurred in the same limb after a period of no or few complaints and in 76 patients RSD recurred in one or more limbs other than the first limb. Compared to 10...

The Escherichia coli Rsd protein forms complexes with the RNA polymerase sigma(70) factor, but its biological role is not understood. Transcriptome analysis shows that overexpression of Rsd causes increased expression from some promoters whose expression depends on the alternative sigma(38) factor, and this was confirmed by experiments with lac fusions at selected promoters. The LP18 substituti...

Social stress is associated with altered immunity and higher incidence of anxiety-related disorders. Repeated social defeat (RSD) is a murine stressor that primes peripheral myeloid cells, activates microglia, and induces anxiety-like behavior. Here we show that RSD-induced anxiety-like behavior corresponded with an exposure-dependent increase in circulating monocytes (CD11b(+)/SSC(lo)/Ly6C(hi)...

The growth-depressing effect of a raw soya-bean diet (RSD) on chicks and rats is well established (Liener, 1962). Pancreatic hypertrophy was observed in both species when given RSD (Chernick, Lepkovsky & Chaikoff, 1948; Booth, Robbins, Ribelin & DeEds, 1960; Alumot & Nitsan, 1961). It was found that chicks given RSD showed markedly depressed proteolytic activity in the small intestine during th...

conclusions the results suggest no significant relationship between the severity of injury and risk of rsd occurrence, although the mean injury severity score was higher in patients with rsd than in those without rsd in this study population. the lower score of local circulation in patients with rsd than in those without rsd is a statistically significant finding and can be attributed to change...

The aim of the present study was to determine if renal sympathetic denervation (RSD) may alleviate isoproterenol-induced left ventricle remodeling, and to identify the underlying mechanism. A total of 70 rats were randomly divided into control (n=15), sham operation (n=15), heart failure (HF) with sham operation (HF + sham; n=20) and HF with treatment (HF + RSD; n=20) groups. The HF model was e...

Reflex sympathetic dystrophy (RSD) is an often devastating chronic pain condition that can develop following relatively trivial traumatic events. The precise mechanism and predisposing factors governing the development and progression of this syndrome are not completely understood. However, RSD most commonly presents distally in an extremity following injury to the limb. Rarely has it been repo...