PURPOSE The purpose of this study was to evaluate the effect of the African potato (AP) on the pharmacokinetics of efavirenz. METHODS; A single-dose, two-phase sequential study was conducted over 31 days in 10 healthy volunteers. On day 1 of the study, volunteers were administered a 600 mg efavirenz tablet, and blood samples were collected before dosing and at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5,...

1. Exogenous microbial beta-1,3-1,4-glucanases and hemicellulases contribute to improving the nutritive value of cereals rich in soluble non-starch polysaccharides for poultry. 2. In general, plant cell wall hydrolases display a modular structure comprising a catalytic module linked to one or more non-catalytic carbohydrate-binding modules (CBMs). Based on primary structure similarity, CBMs hav...

pathophysiology R. K. Gherardi, F.-J. Authier 1) AP-HP, Hôpital H. Mondor, Service d’Histologie et Centre de Référence des Maladies Neuromusculaires (Garches-Necker-Hendaye-Mondor), Créteil, 94000, France ; 2) Université Paris Est, Faculté de Médecine, Créteil, 94000, France ; 3) Inserm, U955, Créteil, 94000, France. Correspondance : Département de Pathologie, Hôpital Henri Mondor, AP-HP, 94000...

Significant research effort has been devoted in the study of approximation algorithms for NP-hard problems. Ap-proximation algorithm for Max-Cut problem with performance guarantee of 0. 87856 is long known. In this work we study balanced Max-Cut problem. We give a balancing factor ? for given ? such that the approximate solution is at least 0. 87856 times the optimal ?-balanced cut and it is it...

Let Sα,ψ( f ) be the square function defined by means of the cone in R n+1 + of aperture α, and a standard kernel ψ . Let [w]Ap denote the Ap characteristic of the weight w. We show that for any 1 < p < ∞ and α ≥ 1, ‖Sα,ψ‖L p(w) αn[w] max ( 1 2 , 1 p−1 ) Ap . For each fixed α the dependence on [w]Ap is sharp. Also, on all class Ap the result is sharp in α. Previously this estimate was proved in...

AIM Left ventricular rotation is an interesting mechanism to investigate patients with heart disease. In children, reference values have to be defined prior to assess pathology. METHODS AND RESULTS One hundred and seventy-four healthy individuals (0-20 years) were investigated by two-dimensional speckle tracking echocardiography, percentiles were created addressing the amount and time-to-peak...

AIMS Cardiac voltage-gated sodium channels control action potential (AP) upstroke and cell excitability. Intracellular calcium (Ca(i)(2+)) regulates AP properties by modulating various ion channels. Whether Ca(i)(2+) modulates sodium channels in ventricular myocytes is unresolved. We studied whether Ca(i)(2+) modulates sodium channels in ventricular myocytes at Ca(i)(2+) concentrations ([Ca(i)(...

To elucidate relationships between meteorological variables and incidence of stroke, we studied patients diagnosed with stroke after presenting to the emergency department (May 1, 2010-August 8, 2011). Patient demographics and medical data were reviewed retrospectively with regional meteorological data. Across 467 days, 134 stroke events were recorded on 114 days. On stroke days, maximum temper...

BACKGROUND Electrophysiological mismatch between host cardiomyocytes and donor cells can directly affect the electrical safety of cardiac cell therapies; however, the ability to study host-donor interactions at the microscopic scale in situ is severely limited. We systematically explored how action potential (AP) differences between cardiomyocytes and other excitable cells modulate vulnerabilit...