The liver has a multitude of functions which are necessary to maintain whole body homeostasis. This requires that various metabolic pathways can run in parallel in the most efficient manner and that futile cycles are kept to a minimum. To a large extent this is achieved due to a functional specialization of the liver parenchyma known as metabolic zonation which is often lost in liver diseases. ...

The establishment of metabolic zonation within a hepatic lobule ascribes specific functions to hepatocytes based on unique, location-dependent gene expression patterns. Recently, there have been significant developments in the field of metabolic liver zonation. A little over a decade ago, the role of β-catenin signaling was identified as a key regulator of gene expression and function in perice...

Abstract: This paper presents the methodology and procedure for flood risk assessment using GIS and flood inundation model (FIM) based on the “micro-zonation concept” in which an entire floodplain considered is divided into numerous unit areas (meshes or grids). In this study, Shinkawa-river floodplain around Nagoya City of Aichi Prefecture in Japan an urbanized lowland area, which was greatly ...

1. introduction flood is one of natural hazard which ranks the most one just like earthquake and drought according to the report of the natural hazard program of the united nations. besides physical factors, and lack proper management will increase the flood potential. therefore, in order to prevent flood damage it seems to be necessary to provide essential requirements before physical expansio...

Biological communities are often structured by environmental factors even at small spatial scales. Fungi are no exception, though the patterns and mechanisms underlying their community structure are usually unknown. Previous work documented zonation in fungi under tree canopies primarily through their fruiting patterns. Here we investigate the existence of zonation patterns in fungal communitie...

nowadays, occurrence of mass movement in the northern forests ofiran, especially in the golestan province is turning to be a usual phenomenon. because of decay of vegetation cover, prediction of landslide occurrence will prevent its damages. landslide hazard zonation is a suitable way in this case. selection of the best model is a way to decrease costs and time. consequently, land slide hazard ...

Ecological risk assessment of mercury contaminant has a means to analyze the ecological aspect ecosystem using potential impact pollution in soil, water and organism. The coastal area can be shown by mangrove zonation, clustering interpolation accumulation. This research aims (including bioaccumulation translocation) indicators species distribution, clustering, zonation results showed that Sega...

The current study presents a detailed assessment of risk zones related to karst collapse in Wuhan by analytical hierarchy process (AHP) and logistic regression (LR) models. results showed that the LR model was more accurate with an area under receiver operating characteristic (ROC) curve 0.911 compared 0.812 derived from AHP model. Both models performed well identifying high-risk only 3% discre...