These lecture notes are intended to recapitulate class lectures. Several notational considerations exist. Namely, appendices to lectures generally provide information not found in the lecture, but are nonetheless helpful for producing a more rigorous understanding of the material; an * (asterisk) next to a proposition, definition, theorem, etc. indicates it was not explicitly written (or mentio...

Three critical aromatic sites have been identified in the yeast galactose transporter Gal2: Tyr(352) at the extracellular boundary of putative transmembrane segment (TM) 7, Tyr(446) in the middle of TM10 and Phe(504) in the middle of TM12. The relationship between these sites was investigated by random mutagenesis of each combination of two of the three residues. Galactose transport-positive cl...

PURPOSE To evaluate the efficacy of photodynamic antimicrobial chemotherapy (PACT) with the new porphyrin derivative TONS 504 and a light-emitting diode (LED) against acyclovir (ACV)-sensitive and -resistant herpes simplex virus type 1 (HSV-1). METHODS Human FL cells infected with the viral strains were subjected to PACT with TONS 504 at various concentrations (0.01 to 10 mg/l) and irradiatio...

IPI-504, a water-soluble ansamycin analogue currently being investigated in clinical trials, is a potent inhibitor of the protein chaperone heat shock protein 90 (Hsp90). Inhibition of Hsp90 by IPI-504 triggers the degradation of important oncogenic client proteins. In cells, the free base of IPI-504 hydroquinone exists in a dynamic redox equilibrium with its corresponding quinone (17-AAG); the...

background: breast cancer is third order malignancy in women among other malignancies.   various studies showed that incidence of breast cancer can be lower down by early detection of breast cancer. mammographic screening is considered more effective modality in detecting early stage breast cancer in women who are at elevated risk for breast cancer. the aim of this study is to report the result...

combining ability and heterosis were studied in a 6×6 partial diallel cross during 2007-2009 to see the nature of gene action in cucumber (cucumis sativus l.). analysis of variance revealed high significant differences among all the f1 hybrid means and among their respective six parental values for all the traits examined. the mean squares attributed to general combining ability (gca) and speci...

Accurately maintaining a fixed limb posture and quickly moving between postures underlies both everyday skills, including holding and lifting a cup of coffee, and expert skills, such as an Olympic wrestler’s holding and throwing an opponent. A fundamental question in limb motor control is whether the brain manages these contrasting goals of posture and movement through a single, robust control ...