N-alkyl azetidines bearing a chiral substituent at the nitrogen atom, and variable C-3 as prochiral centre, react readily with cyanogen bromide even low temperatures to produce corresponding 3-bromo-N-cyanamides diastereoisomeric mixtures via ring opening. This reaction was found be diastereoselective (up 80:20 dr). In one case, major diastereomer could isolated by recrystallization, configurat...

John Chant toward the bud orient the nucleus and spindle for mitosis Figure 1 illustrates the key point that, once a yeast cell has initiated a bud early in the cell cycle, it has Cambridge, Massachusetts 02138 committed to its cleavage plane. The molecular manifestation of commitment is the formation of a ring of septin proteins (Cdc3p, Cdc10p, Cdc11p, and Cdc12p) be-For one cell to divide int...

6-Methyl-2-phenyl-7H-Oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2). Treatment of (1) with hydrazine hydrate gave the corresponding 3-aryl-4H-1,2,4- triazino [4,3-b][1,2,4] triazin-8 (1H)-one (3).

A gene designated thnD, which is required for biodegradation of the organic solvent tetralin by Sphingomonas macrogoltabidus strain TFA, has been identified. Sequence comparison analysis indicated that thnD codes for a carbon-carbon bond serine hydrolase showing highest similarity to hydrolases involved in biodegradation of biphenyl. An insertion mutant defective in ThnD accumulates the ring fi...

Aromatic hydrocarbons are widely distributed in nature. They are found as lignin components, aromatic amino acids and xenobiotic compounds, among others. Microorganisms, mostly bacteria, degrade an impressive variety of such chemical structures. A broad range of peripheral reactions results in a restricted range of central intermediates, which are subject to ring-cleavage and funneling into the...

In the presence of magnesium and hexamethylphosphorictriamide, HMPT, trimethylchlorosilane, TMS-C1, reacts with cyanoepoxides to give related compounds. Ring cleavage at ? - position of cyanoepoxide, 1, followed by the addition of two trimethylsilyl groups leads to 2 then substitution of OSiMei by trimethylsilyl or H takes place to give ?, ? - bis (trimethylsilyl) nitrile or ? - trimethyls...