OBJECTIVE Chloroquine modulates autophagocytic protein degradation in the lysosome system, thereby inducing the formation of rimmed vacuoles consisting of autophagosomes and autolysosomes in skeletal muscle. The goal of this study was to investigate the contribution of the lysosomal system, particularly autophagosome formation (an autophagic process) at the molecular level, to the abnormal accu...

G o o d l o o k i n g . 5 4 y e a r Old William Francis McDon­ ough wears horn-rimmed spec­ tacles, lias steel-gray eyes, talks In a soft, modest way, and is Unmarried. In his day Bill McDonough ^35 been a farmer’s son, soltlier, Merit Man and top execu­ tive of a big-time employees' Sroup. He likes to walk, play golf, and bowl. He once bowled 300, which is as thrilling as ̂ l^ole-in-one is to a...

UNLABELLED A patient developed neck extensor weakness along with symmetrical, mild proximal extremity weakness. Electrodiagnostic findings were minimal. Subsequently muscle biopsy was undertaken which showed myopathic changes as well as rimmed vacuoles. This case highlights the discussion of histopatholgical findings seen in neck extensor weakness when it occurs in isolation as well as when it ...

Data on terrestrial eruptions of pyroclastic material and ballistic considerations suggest that in the lunar environment (vacuum and reduced gravity) low-rimmed pyroclastic rings are formed rather than the high-rimmed cinder cones so abundant on the earth. Dark blanketing deposits in the Taurus-Littrow region (Apollo 17 landing area) are interpreted as being at least partly composed of lunar co...