OBJECTIVES: Previous reports have revealed that several cytokines (including platelet-derived growth factor-BB, transforming growth factors-β1 and insulin-like growth factor-1) can enhance the rate of bone formation and synthesis of extracellular matrix in orthopaedics or periodontology. This study aimed to determine the concentration of cytokines within platelet-rich fibrin microstructures and...

platelets are a natural source of growth factors and cytokines that promote wound healing, and platelet-rich fibrin contains concentrated growth factors. growth factors in platelet-rich fibrin may promote wound repair. in this study the effect of platelet-rich fibrin was evaluated in a dog model of cutaneous incisional wounds using histology and semi-quantitative evaluation. a pair of ten-centi...

UNLABELLED This study evaluated the effect of periarticular pain cocktail, platelet-rich plasma, or fibrin sealant injections on blood loss, transfusion rate, and hospital costs after total knee arthroplasty. A retrospective review of 400 patients undergoing primary total knee arthroplasty with one of the different periarticular treatments as stated above was performed. Postoperative blood loss...

The current study aims to evaluate the macroscopic and histological effects of autologous mesenchymal stem cells (MSC) and platelet-rich plasma on knee articular cartilage regeneration in an experimental model of osteoarthritis. Twenty-four rabbits were randomly divided into four groups: control group, platelet-rich plasma group, autologous MSC undifferentiated group, and autologous MSC differe...

OBJECTIVES Mesenchymal stem cells have the ability to differentiate into various cell types, and thus have emerged as promising alternatives to chondrocytes in cell-based cartilage repair methods. The aim of this experimental study was to investigate the effect of bone marrow derived mesenchymal stem cells combined with platelet rich fibrin on osteochondral defect repair and articular cartilage...

background facial wrinkles develop over the natural aging process. the demand to treat these wrinkles is increasing. several treatment options are available. objectives we aimed to investigate the effect of fat injection and its combination with platelet-rich plasma (prp) on facial wrinkles. patients and methods we recruited 28 patients who were candidates for the treatment of facial wrinkles i...

objectives effect of using autologous platelet-rich plasma (prp) on pain reduction in patients with pilonidal abscess, subjected to extensive surgical removal tissue, was investigated through a clinical trial. patients and methods the trial was conducted on two groups from the center for surgical research at mashhad university of medical sciences located at ghaem hospital in mashhad city in 201...

objective: at present, growth factor-containing products such as enamel matrix derivatives, recombinant bone morphogenetic protein (rh-bmp), recombinant platelet derived growth factor and platelet rich plasma (prp) have gained increasing attention. prp is an autologous source of platelet growth factors used to enhance healing of soft and hard tissues. prp has gained popularity due to its autolo...

Objective- This study aimed to evaluate the feasibility of using platelet rich fibrin membrane as a novel on-lay patching biomaterial in canine esophagotomy and its effects on esophageal wound healing. Design- Experimental study. Animals- Eight adult mixed breed dogs of both sexes equally allocated to control and treatment groups.<b...