Sepsis is a global major health problem in great need for more effective therapy. For thousands of years, Rhubarb had been used for various diseases including severe infection. Pharmacological studies and trials reported that Rhubarb may be effective in treating sepsis, but the efficacy and the quality of evidence remain unclear since there is no systematic review on Rhubarb for sepsis. The pre...

We have studied the effects of various Kampo medicines on P-glycoprotein (P-gp), a drug transporter, in vitro. The present study focused on Daiokanzoto (Da-Huang-Gan-Cao-Tang), which shows the most potent inhibitory effects on P-gp among the 50 Kampo medicines studied, and investigated the P-gp inhibitory effects of Daiokanzoto herbal ingredients (rhubarb and licorice root) and their components...

Insect floral herbivory can dramatically reduce plant reproductive success. Thus, plants should have evolved mechanisms that minimize the effect of insect herbivores, particularly in monocarpic species that must maximize fitness in a single flowering year. Tolerance is one such mechanism; however, few experiments to date evaluate underlying mechanisms of plant tolerance under natural conditions...

this study was carried out to investigate flower yield and yield components in iranian rosa damascena using 20 genotypes, collected from different regions of iran and grown in drylands and deserts research station of kashan, iran, using a randomized complete block design with three replications in 2007-2008. flower yield per plant, number of flowers per plant, plant height, leaf length, width, ...

background & aim: german chamomile is one of the most important medicinal plants. so, assessment of genetic diversity and relationship among the traits are very essential in chamomile breeding programs. determination of the best indirect selection criteria for genetic improvement of essence percent and dry flower yield of german chamomile (matricaria chamomilla l.) populations was investiga...

The present study investigates the qualitative and quantitative analysis of the major bioactive constituents of medicinally important plant Taraxacum officinale in its aqueous and methanol extract of root, stem and flower. Saponins, flavonoids, alkaloids, phenols were highly concentrated in the stem, root and flower, with the higher concentration of flavonoids in the flower extracts. Phenols an...

AIM To investigate the effects of rhubarb enema treatment using a 5/6 nephrectomized rat model and study its mechanisms. METHODS Twenty-eight Sprague Dawley rats were divided into three groups: sham operation group (n = 8), 5/6 nephrectomized (5/6Nx) (n = 10), and 5/6Nx with rhubarb enema treatment (n = 10). The rhubarb enema was continuous for 1.0 month. Serum creatinine, serum indoxyl sulfa...

The aim of our study was to investigate the mechanisms by which rhubarb regulates β-catenin as well as metastasis of hepatocellular carcinomas. Our results revealed that rhubarb extract inhibited HA22T cell migration ability in wound healing, migration and invasion assays in a dose-dependent manner. Rhubarb also reduced β-catenin protein level, downregulated its downstream proteins, cyclin D, T...

Rhubarb (Rheum rhapontiam) stalk fibre was previously shown to be hypolipidaemic under clinical and experimental conditions. The present study was undertaken to investigate whether rhubarb stalk fibre has a hypolipidaemic effect under diabetic conditions. Two models of diabetic rats were used: streptozotocin-induced diabetic rats, and diabetes-prone BB (BBdp) rats. The plasma cholesterol and tr...

zThe coding sequence is compared for each pair of genes. Comparisons were done using the gap program of the Wisconsin GCG sequence analysis package. yCHS = chalcone synthase; CHI = chalcone isomerase; DFR = dihydroflavonol reductase. xFirst row for each plant pair presents the percent amino acid similarity. wSecond row for each plant pair presents the percent amino acid identity. vThird row for...