Rhubarb (Rheum emodi) is an important medicinal plant, which finds an extensive use in Ayurveda and Unani system of medicine. Rhubarb (Rheum emodi, family Polygonaceae) has been traditionally used as diuretic, liver stimulant, purgative/cathartic, stomachic, Antitumour, anticholesterolaemic, antiseptic, wound healer, antidiabetic and tonic. The most important constituents from rhubarb are the f...

Chronic kidney disease (CKD) is a major public health problem worldwide. Rhubarb has been shown to have nephroprotective and anti-fibrotic activities in patients with CKD. However, bioactive fractions and biochemical mechanism of anti-fibrotic properties of rhubarb remain unclear. Here we applied ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry together with u...

BACKGROUND Rhubarb is an important Chinese medicinal herb with a long history of over 2000 years and has been commonly used as a laxative. It is the radix and rhizome of Rheum officinale Baill., R. palmatum L. and R. tanguticum Maxim, all of which are mainly distributed in a broad region in the Tibetan plateau. Anthraquinone glycosides are a series of major active ingredients found in all three...

CLIFFORD M. FOUST, Rhubarb: the wondrous drug, Princeton University Press, 1992, pp. xxii, 371, illus., £27.50 (0-691-08747-4) Children in Russia during the 1960s were fully aware of the existence of rhubarb which, together with castor oil, was one of the staple home medicines. Attitudes varied according to the method of administration. The lucky ones consumed it as compotes and kissels, others...

CLIFFORD M. FOUST, Rhubarb: the wondrous drug, Princeton University Press, 1992, pp. xxii, 371, illus., £27.50 (0-691-08747-4) Children in Russia during the 1960s were fully aware of the existence of rhubarb which, together with castor oil, was one of the staple home medicines. Attitudes varied according to the method of administration. The lucky ones consumed it as compotes and kissels, others...

SCOPE Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by hepatic inflammation and oxidative stress, which could be promoted by gut barrier function alterations. In this study, we have tested the hypothesis of the hepatoprotective effect of rhubarb extract in a mouse model of binge drinking and we explored the contribution of the gut...

BACKGROUND Renal fibrosis is common in progressive kidney disease. Transforming growth factors β (TGF-β) are important mediators of all types of fibrosis, including renal fibrosis. Chinese rhubarb has been shown to have antifibrotic properties in part because of inhibition of TGF-β and has slowed the progression of kidney disease in rodent models. HYPOTHESIS That administration of a Chinese r...

Blood-brain barrier (BBB) disruption is a key pathophysiological factor of intracerebral hemorrhage (ICH). The level of zonula occludens-1 (ZO-1) has been closely associated with the degree of BBB damage, and is an indicator of BBB destruction. The aim of the present study was to evaluate the effects of rhubarb on BBB function in a rat model of ICH. ICH was induced in rats by treatment with typ...

Rhubarb (Dahuang in Chinese), a well-known chinese herbal medicine, has long been used in the world and is officially listed in Chinese Pharmacopoeia which containing three species, Rheum palmatum L., Rheum officinale Bail and Rheum tanguticum Maxim. ex Balf. [1]. It is also formally listed in European and Japanese Pharmacopoeia [2,3]. This important herbal medicine has been discerned for centu...

Rhubarb (Rheum tanguticum; da-huang in Chinese medicine) is a herbal medicine that has been used widely for managing fever and removing toxicity. In this study, we investigated how rhubarb inhibits influenza virus during the early stage of the infectious cycle using different functional assays. A non-toxic ethanolic extract of rhubarb (Rex) inhibited several H1N1 subtypes of influenza A viruses...