BACKGROUND High morbidity and mortality due to Rheumatic heart disease (RHD) associated with females is mainly because of late diagnosis on one hand and socioeconomic reasons on the other hand. Poor referral to tertiary care centres leads to delayed diagnosis which results in complications. The objectives of this cross-sectional descriptive study was to assess the frequency of severe mitral ste...

BACKGROUND We examined predictors of early and very long-term outcome after combined mitral and tricuspid valve repair for rheumatic disease. METHODS AND RESULTS Between 1974 and 2002, 153 consecutive patients (mean age, 46.0+/-13.2 years) underwent combined mitral and tricuspid valve repair for rheumatic disease. Mitral disease was predominantly stenosis (82.3%); 100% of patients had organic...

The M mode and two dimensional echocardiographic and the left ventricular end diastolic pressure was abnormalities of ruptured chorda tendinae of the mitral 18 mm Hg. Left ventricular angiography showed a dilated valve leaflets in non-rheumatic mitral valve disease have left ventricle with good contraction and severe grade IV been well documented.' 2 Echocardiographic abnormalities mitral regur...

Background—We examined predictors of early and very long-term outcome after combined mitral and tricuspid valve repair for rheumatic disease. Methods and Results—Between 1974 and 2002, 153 consecutive patients (mean age, 46.0 13.2 years) underwent combined mitral and tricuspid valve repair for rheumatic disease. Mitral disease was predominantly stenosis (82.3%); 100% of patients had organic tri...

BACKGROUND Rheumatic heart disease is the most common cause of valvular disease in developing countries. Despite the high prevalence of this disease, the cellular mechanisms are not well known. We hypothesized that rheumatic valve calcification is associated with an osteoblast bone formation and neoangiogenesis. METHODS AND RESULTS To test this hypothesis, we examined human rheumatic valves r...

Rheumatic valve disease, a consequence of acute rheumatic fever, remains endemic in developing countries in the sub-Saharan region where it is the leading cause of heart failure and cardiovascular death, involving predominantly a young population. The involvement of the mitral valve is pathognomonic and mitral surgery has become the lone therapeutic option for the majority of these patients. Ho...

Over the past 25 to 30 years advances in therapeutics and pathology have considerably modified traditional concepts of valve disease, band much of the earlier literature of cardiac pathology has become mainly of historic interest. The introduction of antibiotics changed the pathology and course of infective endocarditis and is reducing the incidence of chronic rheumatic and syphilitic valve dis...

BACKGROUND Rheumatic heart disease is an autoimmune disease caused by group A streptococci infection and frequently affects the aortic valve. Sex differences are common in the disease progression, treatment, and outcome. However, little is known about the sex differences in the pathology of aortic valves in rheumatic heart disease. DESIGN We studied the end-stage calcific aortic valves from m...

BACKGROUND Mitral valve repair in rheumatic disease is technically more difficult, and there is little information on the long-term stability of this technique. METHODS AND RESULTS From January 1975 to December 1990, 327 patients underwent mitral valve repair with the Duran flexible ring annuloplasty for rheumatic valve disease. Mean age was 45.4 +/- 12.6 years (range, 23 to 73 years). The te...