Objective: The present study was designed to investigate the protective effects of hydroalcoholic extract of Rheum turkestanicum against HgCl2 hepatorenal toxicity in rats. Materials and Methods: Animals were randomly divided into five groups (n= 6 in each group) and received HgCl2 and plant’s extract, intraperitoneally. Group1 received saline (1 mL/kg/day), group 2 received extract (200 mg/kg/...

The neglected blood flukes Orientobilharzia spp. belonging to the Platyhelminthes, infect animals in a number of countries of the world, and cause cercarial dermatitis in humans, as well as significant diseases and even death in economically-important animals. MicroRNAs (miRNAs) are now considered to be a key mechanism of gene regulation. Herein, we investigated the global miRNA expression prof...

background: adult worms of orientobilharzia turkestanicum live in the portal veins, or intestinal veins of cattle, sheep, goat and many other mammals caus-ing orientobilharziasis. orientobilharziasis causes significant economic losses to livestock industry of iran. however, there is limited information about genotypes of o. turkestanicum in iran. methods: in this study, 30 isolates of o. turkes...

s and/or oral presentations presented at American College of Rheumatology (ACR) 2010, 2011 and 2012: 1. Pickens SR, Volin MV, Mandelin II AM, Shahrara S. Local expression of IL-27 ameliorate collagen induced arthritis. Arthritis Rheum 714: S298, 2010. Oral presentation 2. Pickens SR, Volin MV, Pope RM, Mandelin II AM, Shahrara S. Characterization of CCR7 and its ligands CCL19 and CCL21 in rheum...

trematodes are important in economic and public health. ornithobilharzia turkestanicum (o. turkestanicum) is one of the important economic trematodes in domestic animals. ornithobilharzia infection in intermediate host (lymnaea gedrosiana ) can be detected by either exposing snails to light to induce cercarial shedding or by squeezing them between glass slides to detect parasites. the current a...

OBJECTIVE AI/RHEUM is a multimedia expert system developed originally to assist in the diagnosis of rheumatic diseases in adults. In the present study we evaluated the usefulness of a modified version of this diagnostic decision support system in diagnosing childhood rheumatic diseases. METHODOLOGY AI/RHEUM was modified by the addition of 5 new diseases to the knowledge base of the system. Cr...

Two new resveratrol trimer derivatives, named rheumlhasol A (1) and rheumlhasol B (2) were isolated from the methanolic extract of roots of Rheum lhasaense A. J. Li et P. K. Hsiao together with four known resveratrol dimer derivatives, including maximol A (3), gnetin C (4), ε-viniferin (5), and pallidol (6). The structures were determined by combined spectroscopic methods and by comparison of t...