OBJECTIVE AI/RHEUM is a multimedia expert system developed originally to assist in the diagnosis of rheumatic diseases in adults. In the present study we evaluated the usefulness of a modified version of this diagnostic decision support system in diagnosing childhood rheumatic diseases. METHODOLOGY AI/RHEUM was modified by the addition of 5 new diseases to the knowledge base of the system. Cr...

Two new resveratrol trimer derivatives, named rheumlhasol A (1) and rheumlhasol B (2) were isolated from the methanolic extract of roots of Rheum lhasaense A. J. Li et P. K. Hsiao together with four known resveratrol dimer derivatives, including maximol A (3), gnetin C (4), ε-viniferin (5), and pallidol (6). The structures were determined by combined spectroscopic methods and by comparison of t...

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BACKGROUND AND AIMS Rheum, a highly diversified genus with about 60 species, is mainly confined to the mountainous and desert regions of the Qinghai-Tibetan plateau and adjacent areas. This genus represents a good example of the extensive diversification of the temperate genera in the Qinghai-Tibetan plateau, in which the forces to drive diversification remain unknown. To date, the infrageneric...

ankylosing spondylitis. Arthritis Rheum 2006;54:2845–51. 17. Rudwaleit M, Schwarzlose S, Hilgert ES, Listing J, Braun J, Sieper J. MRI in predicting a major clinical response to anti-tumour necrosis factor treatment in ankylosing spondylitis. Ann Rheum Dis 2008;67:1276–81. 18. Bennett AN, Rehman A, Hensor EMA, Marzo-Ortega H, Emery P, Mc Gonagle D. Evaluation of the diagnostic utility of spinal...

Rhaponticum carthamoides plants ("maral root") are widely used in Siberian folk medicine. The present study reports for the first time the presence of pentacyclic terpenoid, α-amyrin, in methanol extract from leaves of this plant. α-Amyrin induced proliferation of human keratinocytes (HaCaT) by about 18% while other extract components were ineffective. A panel of biochemical and cell-based ass...

3 Tan E M, Rodnan G P, Garcia I, Moroi Y, FritzlerM J, Peebles C. Diversity of antinuclear antibodies in progressive systemic sclerosis. Arthritis Rheum 1980; 23: 617-25. 4 Giordano M. Classification of progressive systemnic sclerosis. International Conference on PSS (scleroderma). Austin, 20-23 October 1981. Arthritis Rheum in press. 5 Giordano M, Valentini G, Ara M, Tirri G, Capeili L, Vatti ...