نتایج جستجو برای: rfrp

تعداد نتایج: 97  

Journal: :General and comparative endocrinology 2010
Sumit Sethi Kazuyoshi Tsutsui Chandra Mohini Chaturvedi

The present study analyzed changes in the expression of RFamide-related peptide-3 (RFRP-3; a mammalian ortholog of avian gonadotropin-inhibitory hormone), in the brain and correlated it with testicular activity of mice of different age groups (day-old, 1-, 3-, 5-, 7-, 9-, 11-, 13-week and 1.5-year-old). Testicular activity after a progressive increase up to 13-week of age declined in the old mi...

2014
Fatemeh Sabet Sarvestani Amin Tamadon Omid Koohi-Hosseinabadi Saeed Mohammadi Nezhad Farhad Rahmanifar Mohammad Reza Jafarzadeh Shirazi Nader Tanideh Ali Moghadam Ali Niazi

BACKGROUND RFamide-related peptide-3 (RFRP-3) and kisspeptin (KiSS-1) are known to respectively inhibit and stimulate gonadotropin releasing hormone (GnRH) and lute- inizing hormone (LH) secretion in rat. The aim of the present study was to evaluate the relative mRNA expression of RFRP-3 and KiSS-1 in the hypothalamus of pregnant rats. MATERIALS AND METHODS In a randomized controlled experime...

Journal: :Experimental animals 2016
Xingang Dan Li Han Hasan Riaz Xuan Luo Xiaoran Liu Zhenglu Chong Liguo Yang

To further improve fertility of animals, a novel gene RFRP-3 (RF-amide related peptide-3, RFRP-3) was used to construct DNA vaccines with INH α (1-32) (inhibin, INH) fragment for the first time. The aim of this study was to evaluate the effects of novel DNA vaccines on fertility in mice. Synthesized SINH and SRFRP (INH and RFRP genes were separately ligated to the C-terminus of the small envelo...

Journal: :Journal of Medicinal Chemistry 2021

RFamide-related peptide-3 (RFRP-3) and neuropeptide FF (NPFF) target two different receptor subtypes called FF1 (NPFF1R) FF2 (NPFF2R) that modulate several functions. However, the study of their respective role is severely limited by absence selective blockers. We describe here design a highly NPFF1R antagonist RF3286, which potently blocks RFRP-3-induced hyperalgesia in mice luteinizing hormon...

2016
Maliheh Jahanara Amin Tamadon Mohammad Reza Jafarzadeh Shirazi Farhad Rahmanifar Nader Tanideh Ali Moghadam Ali Niazi

Introduction: Arginine-phenylalanine-amide-related peptide-3 (RFRP-3) is an inhibitor of gonadotropin releasing hormone (GnRH) secretion and an appetizer. Kisspeptin is a stimulator of GnRH and a regulator of energy metabolism. The objectives of the present study were to compare the effect of long term malnutrition on expression of RFRP-3 mRNA in dorsomedial hypothalamic nucleus (DMH) and KiSS-...

Journal: :Molecular and cellular endocrinology 2015
Sheila J Semaan Alexander S Kauffman

Puberty is governed by the secretion of gonadotropin releasing hormone (GnRH), but the roles and identities of upstream neuropeptides that control and time puberty remain poorly understood. Indeed, how various reproductive neural gene systems change before and during puberty, and in relation to one another, is not well-characterized. We detailed the daily pubertal profile (from postnatal day [P...

2017
Jill E Schneider Noah A Benton Kim A Russo Candice M Klingerman Wilbur P Williams Jessica Simberlund Amir Abdulhay Jeremy M Brozek Lance J Kriegsfeld

Ingestive and sex behaviors are important for individual survival and reproductive success, but when environmental energy availability is limited, individuals of many different species make a trade-off, forfeiting sex for ingestive behavior. For example, food-deprived female Syrian hamsters (Mesocricetus auratus) forego vaginal scent marking and lordosis (sex behaviors) in favor of foraging, ho...

ژورنال: :physiology and pharmacology 0
محمد رضا جعفرزاده شیرازی mohammad reza jafarzadeh shirazi dept. of animal sciences, college of agriculture, shiraz university, shiraz, iran فرید پژوهی farid pazoohi dept. of animal sciences, college of agriculture, shiraz university, shiraz, iran محمد جواد ضمیری mohammad javad zamiri dept. of animal sciences, college of agriculture, shiraz university, shiraz, iran محمد سعید صالحی mohammad saeed salehi dept. of animal sciences, college of agriculture, shiraz university, shiraz, iran محمد رضا نام آور mohammad reza namavar histomorphometry and stereology research center & dept. of anatomical sciences, school of medicine, shiraz, university of medical sciences, shiraz, iran امین تمدن amin tamadon dept. of clinical sciences, school of veterinary medicine, shiraz university & infertility research center, shiraz,university of medical sciences, shiraz, iran نادر تنیده

مقدمه: پپتید وابسته به آرژنین ـ فنیل آلانین ـ آمید (rfrp) به عنوان فاکتور مهارکننده تراوش هورمون آزادکننده گونادوتروپین (gnrh) شناخته شده است. هدف پژوهش کنونی بررسی الگوی بیان rfrp در نورون های هسته پشتی ـ میانی (dmh) هیپوتالاموس موش های صحرایی در گامه های مختلف چرخه فحلی بود. روش ها: در این پژوهش گامه های مختلف چرخه فحلی در 16 موش صحرایی ماده بزرگسال اسپراگ داولی با روش گسترش مهبلی تعیین شد. م...

Introduction: RFamide-related peptide (RFRP) is believed to act as an inhibitor of gonadotropin releasing hormone (GnRH) secretion. The aim of the present study was to compare the expression pattern of RFRP neurons in the dorsomedial nucleus of hypothalamus (DMH) at different phases of the rat estrous cycle. Methods: The phases of the estrous cycle were determined in 16 adult female Sprague-...

Journal: :international journal of fertility and sterility 0
atefeh noroozi mohammad reza jafarzadeh shirazi amin tamadon ali moghadam ali niazi

background: rfamide-related peptide-3 (rfrp-3) inhibits gonadotropin releasing hormone (gnrh) and luteinizing hormone (lh) secretion in rats. this study evaluates the effects of litter size and suckling intensity on rfrp mrna expression in the dorsomedial hypothalamic nucleus (dmh) of rats. materials and methods: a total of 32 pregnant and 4 non-lactating ovariectomized (control group) sprague-...

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