OBJECTIVES Bipolar disorder (BD) is a highly heritable disorder with polygenic inheritance. Among the most consistent findings from functional magnetic imaging (fMRI) studies are limbic hyperactivation and dorsal hypoactivation. However, the relation between reported brain functional abnormalities and underlying genetic risk remains elusive. This is the first cross-sectional study applying a wh...

Plant growth regulators (PGRs) are exogenously applied chemicals that alter plant metabolism, cell division, cell enlargement, growth and development by regulating plant hormones or other biological signals. For example, some PGRs regulate stem elongation by inhibiting biosynthesis of gibberellins or through releasing ethylene. PGR effects are widely studied and reported on barley (Hordeum vulg...

The cotton plant is a perennial with an indeterminate growth habit, and reputed to have the most complex growth habit of all major row crops. Furthermore, it is very responsive to management and changes in the environments and responds to any perturbations in its environment with a dynamic growth response that is often unpredictable. Cotton producers and researchers have, therefore, used plant ...

OBJECTIVE To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS We computed polygenic risk scores (PGRS) using summary statistics from the International Genomics of Alzheimer's Project genome-wide association study of AD. Associations between ...

• j ermudagrass is a popular turfgrass used on athletic fields • due to its aggressive summer growth habit, fine leaf texhue, and dark green color. However, if mowed infre• quently, excessive scalping and dipping production combine to decrease its aesthetic quality. Plant growth fl:'gulalors (PGRs) were introduced into the turf industry in the 1950's and since have been used in part to reduce m...

ABSORPTION AND RELEASE OF MITOMYCIN-C BY “SPONGOSTAN FILM”. LARROSA JMl, FERRER J2, PINILLA 11, POLO VI, SANCHEZ Al, BUENO J’, HONRUBIA FMl. 1 Department of Ophthalmology, “Miguel Set-vet” Hospital. Zaragoza,(Spain) 2 Department of Microbiology, Puroose: To determine the Mitomycin-C (MMC) 0,4 mg./ml. absorption of spumous specimens of “Spongostan Film” (“Sp”) and their liberation rate. Methods:...

We sought to determine whether nonrandom association of IS6110 with Mycobacterium tuberculosis could result in false-positive clustering in unselected collections of isolates. We typed 196 strains of M. tuberculosis from an unselected community-based study in northern Tanzania by IS6110 and polymorphic GC-rich repetitive-sequence (PGRS) methodologies. The strains were analyzed by Gelcompar comp...

PE_PGRS proteins are unique to the Mycobacterium tuberculosis complex and a number of other pathogenic mycobacteria. PE_PGRS30, which is required for the full virulence of M. tuberculosis (Mtb), has three main domains, i.e. an N-terminal PE domain, repetitive PGRS domain and the unique C-terminal domain. To investigate the role of these domains, we expressed a GFP-tagged PE_PGRS30 protein and a...

Evidence suggests that there is shared genetic aetiology across the major psychiatric disorders conferred by additive effects of many common variants. Measuring their joint effects on brain function may identify common neural risk mechanisms. We investigated the effects of a cross-disorder polygenic risk score (PGRS), based on additive effects of genetic susceptibility to the five major psychia...