PURPOSE To determine the effects of X-linked and autosomal recessive Alport syndrome on retinal basement membranes and how these result in the characteristic perimacular dot-and-fleck retinopathy, lozenge, and macular hole. METHODS The type IV collagen chains present in the normal retina were determined immunohistochemically. Ten patients with Alport syndrome underwent retinal photography and...

SUMMARY The use of in vivo confocal microscopy (IVCM) is rapidly emerging as an important clinical tool to evaluate changes in corneal sensory nerves as a surrogate measure for diabetic peripheral neuropathy. Commonly used metrics to document and grade the severity of diabetes and risk for diabetic peripheral neuropathy include nerve fiber length, density, branching and tortuosity. In addition ...

BACKGROUND To find the correlations and differences between the nerve fiber layer parameters of a GDx (polarimetric retinal nerve fiber analyzer) in single high quality images and those in the mean image from three high quality images. METHODS The results of scanning laser polarimetry were selected from 63 eyes of 63 patients (31 male and 32 female). Complete ophthalmic examinations included ...

PURPOSE This study was designed to assess and compare the thicknesses of the fovea and the retinal nerve fiber layer in normal children and children with amblyopia. METHODS Optical Coherence Tomography (OCT) was performed on 26 children (52 eyes total) with unilateral amblyopia that was due to anisometropia or strabismus. OCT was also performed on 42 normal children (84 eyes), for a total of ...

The relationship of the vasculature to the neuronal layers was studied in whole-mounts and in sections of macaque retinas. Like other central nervous structures, primate retinas have local variations in vascularity that reflect local variations in metabolism, rather than simply tissue thickness or volume. A special feature of the retina is a dense vascular plexus in the nerve fiber layer, which...

PURPOSES To evaluate the retinal nerve fiber layer using GDx in chronic alcohol and tobacco users. METHODS Twenty-three chronic alcohol and tobacco users were studied (study group). As a control group, sixteen volunteers without use of alcohol and tobacco with similar characteristics (age, gender and race) were included. Both eyes were tested for analysis of the retinal nerve fiber layer with...

purpose : this study was designed to assess and compare the thickness of the peripapillar retinal nerve fiber layer (rnfl) in amblyopic and normal eyes in unilateral strabismic ambelyopia using scanning laser polarimeter. methods : scanning laser polarimetry was performed on 17 patients with unilateral strabismic amblyopia who had an absence of neurologic diseases or glaucoma with a minimum age...

PURPOSE To investigate retinal changes prior to vascular signs in patients with type 2 diabetes without diabetic retinopathy or with mild non proliferative diabetic retinopathy. METHODS A cross-sectional study was performed in three groups: patients without diabetes, patients with type 2 diabetes without diabetic retinopathy, and patients with diabetes with mild diabetic retinopathy. Analysis...