conclusions we found ccd and rsm very effective in optimizing hib culture conditions, and hib biomass production was greatly influenced by ph and incubation temperature. therefore, optimization of the growth factors to maximize hib production can lead to 1) an increase in bacterial biomass and prp productions, 2) lower vaccine prices, 3) vaccination of more susceptible populations, and 4) lower...

There have been many productive methods developed so far for optimization of multiple response surface (MRS) problems. This paper tends to review the most seminal approaches in MRS and discuss the strength and weakness of each of the approaches through existing aspects in MRS. A numerical example is included to compare results by different methods. Finally some of the prominent areas for future...

low grade grape juice concentrate was used as carbon source for xanthan production. significant factors affecting xanthan concentration, productivity and viscosity were investigated using plackett-burman design. based on the obtained results, carbon and nitrogen concentrations, inoculum size and agitation rate, were assumed as significant factors. broth culture viscosity and xanthan concentrati...

in this study, modeling and optimization of coagulation and flocculation processes in cod removal of galvanized wastewater treatment plant of mobarakeh steel complex (msc) were studied. experiments of this study were designed using response surface method which is one of the most efficient methods in experimental design. the variables assessed in this study, are four factors including ph, input...

Response surface methodology is a common tool in optimizing processes. It mainly concerns situations when there is only one response of interest. However, many designed experiments often involve simultaneous optimization of several quality characteristics. This is called a Multiresponse Surface Optimization problem. A common approach in dealing with these problems is to apply desirability funct...

Since Amaranth (AM) is one of the dye compounds which is harmful to human’s life its removal from industrial waste water would reduce their environmental impact and health effect. Copper nanoparticle (CuNP) is a simple and eco-friendly material which can be used to remove this pollutant. In this paper, copper nanoparticles were synthesized, for removal of AM dye. The experiments were designed b...

in design of experiments, analysis and identifying those variables that affect the outputs are of interest. response surface methodology is a mathematical-statistical method to optimize the experiment outputs. this method tries to find the best response levels by optimizing the design variables called factors. in many engineering applications, robust design has become the most important issues....

conclusions the results of this study show that it is possible to remove nitrate, and its intermediates from waste water. regarding the desirability of the process, the field scale study is proposed. results the results showed that by applying electric current of 0.14 a for 120 minutes, the nitrate content would reduce down to 97%. the obtained r2 for the nitrate removal model was higher than 0...

Optimization of the sectional wing in ground effect (WIG) has been studied using ahigh order numerical procedure and response surface method (RSM). Initially, the effects of the ground clearance, angle of attack, thickness, and camber of wing have been investigated by a high-resolutionscheme, which is highlystrong and accurate. In the numerical simulation, Normalized Variable Diagram (NVD) sche...