نتایج جستجو برای: respectively three different genotypic variants including aa
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Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity
BACKGROUND Colorectal cancer (CRC) is the second most commonly diagnosed cancer and the fourth leading cause of cancer-related mortality around the world. OBJECTIVES With regard to the role of obesity in colorectal cancer (CRC) and the role of leptin in obesity, we investigated whether leptin (LEP) and leptin receptor (LEPR) gene variants are associated with CRC risk. PATIENTS AND METHODS W...
multiple sclerosis (ms) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. genetic predisposition has long been suspected in the etiology of this disease. the association between mthfr polymorphisms and ms has been ivestigated in different ethnic groups. we investigated the association between mthfr c677t and a1298c missense variants and ms in 180 patients ...
N most of the existing theory of selection the genotypes present in a population I are assumed to have constant selective advantages or disadvantages in relation to each other. But a different case was considered by HALDANE (1 961 ) . He assumed that generations do not overlap and that in each generation a proportion C of the males and a proportion c of the females are removed from the populati...
Catechol-O-methyl transferase (COMT) gene variants are involved in different neuropsychiatric disorders and cognitive impairments, associated with altered dopamine function. This study investigated the genotypic haplotypic association of COMT rs4680 rs4618 polymorphisms severity other clinical symptoms 544 male 385 female subjects schizophrenia. rs4818 G carriers were more frequent patients mil...
Potassium-azeloyl-diglycinate is an active ingredient as a sebum normalizer and skin lightening-agent to moisturize treat hyperpigmentation. Anti-aging (AA) cream cosmetic used prevent premature aging. The use of emulsifying agent necessary produce stable cream. One the commonly emulsifying-agents triethanolamine. This study aims formulate AA-cream potassium-azeloyl-diglycinate preparation vari...
Vitamin D is getting more attention everyday due to its importance in maintaining bone and calcium homeostasis, cellular proliferation, differentiation and immune response. Vitamin D is derived from diet or elicited in the skin by the activation of 7-dehydrocholesterol, which is an inert molecule that must be activated by ultraviolet light to form pre-vitamin D3. Recent studies connected the ge...
results no significant correlation was seen in rs3743527 and rs129081 polymorphism’s allelic and genotypic frequencies between the patient group and control individuals (p value > 0.05). the average frequencies of rs129081 g and c alleles was 40 (58%) and 29 (42%), respectively. in our sample the average frequencies of rs3743527 c and t alleles, were 41 (61%) and 28 (39%), respectively. the res...
Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the chromosome 1q32 locus linked to SLE, have been associated with multiple human diseases and may contribute to dysregulated complement activation predisp...
Point mutations in exon IV of the bovine κ-casein (CSN3) gene determine two allelic variants, A and B. These variants were distinguished by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis in the indigenous Sahiwal and Tharparkar cattle breeds. DNA samples (252 Sahiwal and 56 Tharparkar) were analyzed for allelic variants of the CSN3 gene. Polymorphism ...
OBJECTIVE This study aimed to investigate whether or not hypoxia-inducible factor-1α (HIF-1α) gene variants are associated with the susceptibility and clinical characteristics of lumbar disc degeneration (LDD). METHODS We examined 320 patients with LDD and 447 gender- and age-matched control subjects. We also determined the HIF-1α gene variants, including C1772T (P582S) and G1790A (A588T) pol...
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