The antitumor drug Etoposide (ETO) induces DNA double-strand breaks (DSB) and is associated with the development of secondary neoplasms in treated patients. DSB are repaired by two main mechanisms, homologous recombination (HR) classical non-homologous end joining (c-NHEJ). When HR c-NHEJ defective, PARP-1-dependent alternative end-joining (alt-EJ) pathway. involvement alt-EJ progression induce...

We introduce a novel semantic representation formalism, Almost Flat Functional semantics (AFF), which is designed as an intelligent compromise between linguistically motivated predicate/argument semantics and ad hoc engineering solutions based on flat feature/value lists; the central idea is to tag each semantic element with the functional marking which most closely surrounds it. We argue that ...

The Registro Informatizado de Enfermedad TromboEmbólica (RIETE Registry) is an ongoing, international, prospective registry of consecutive patients with acute venous thromboembolism (VTE) designed to gather and analyze data on treatment patterns and outcomes in patients with acute VTE. It started in Spain in 2001, and 6 years later the database was translated into English with the aim to expand...

BACKGROUND Efforts to improve quality of care for patients with acute myocardial infarction (AMI) are a national priority. To date, there have been few studies that have prospectively evaluated hospital quality improvement (QI) interventions. METHODS AND RESULTS Using hospitals in the National Cardiovascular Data Registry (NCDR) ACTION Registry-GWTG, a cluster randomized trial of the effectiv...

This paper describes the Advanced Forensic Format (AFF), which is designed as an alternative to current proprietary disk image formats. AFF offers two significant benefits. First, it is more flexible because it allows extensive metadata to be stored with images. Second, AFF images consume less disk space than images in other formats (e.g., EnCase images). This paper also describes the Advanced ...

We study the existential closures of several propositional languages L considered recently as target languages for knowledge compilation (KC), namely the incomplete fragments KROM-C, HORN-C, K/H-C, renH-C, AFF, and the corresponding disjunction closures KROM-C[∨], HORN-C[∨], K/H-C[∨], renH-C[∨], and AFF[∨]. We analyze the queries, transformations, expressiveness and succinctness of the resultin...

background: use of cellular phones emitting radiofrequency electromagnetic field (rf-emf) has been increased exponentially and become a part of everyday life. this study aimed to investigate the effects of in vitro rf-emf exposure emitted from cellular phones on sperm motility index, sperm dna fragmentation and seminal clusterin (clu) gene expression. materials and methods: in this prospective ...