Cystic fibrosis (CF) is a life-limiting autosomal recessive disorder affecting principally respiratory and digestive system. It is caused by cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation. The aim of this study was to determine the extent of repeat numbers and the degree of heterozygosity for c.3499+200TA(7_56) and D7S523 located in intron 17b and 1 cM proximal to the ...

BACKGROUND The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable acc...

STUDY OBJECTIVES Cystic fibrosis (CF) patients may be predisposed to poor sleep quality due to upper and lower airway abnormalities and impaired gas exchange. Previous sleep investigations of CF patients using single-night polysomnography have reported conflicting results. We hypothesized that sampling sleep for a prolonged period in a patient's normal environment may give a more representative...

Abstract The main goal of this study is optimization of densification of ZrB2-SiC composites reinforced with chopped Cf prepared by SPS. Taguchi method is employed as statistical design of experiment (DOE) to optimize densification parameters including SiC, Cf, MoSi2, HfB2 and ZrC content, milling time of Cf and SPS parameters such as temperature, time and pressure. Each of these factors ...

The all-dielectric metasurface-based color filter (CF) has attracted huge interest in many fields due to its excellent optical properties. We present four CFs with different shapes on quartz substrates generate blue (B), green (G), and red (R) spectra high purity. show the maximum reflection intensities of 99.6% 99.7% 95.1% (R), their bandwidths are 14, 16, 13 nm for RGB colors, respectively. T...

BACKGROUND and study objectives: Patients with end-stage cystic fibrosis (CF) develop respiratory failure and hypercapnia. In contrast to COPD patients, altered electrolyte transport and malnutrition in CF patients may predispose them to metabolic alkalosis and, therefore, may contribute to hypercapnia. The aim of this study was to determine the prevalence of metabolic alkalosis in adults with ...

Persistent presence of PMN in airways is the hallmark of CF. Our aim was to assess PMN adherence, percentage of apoptotic airway PMN (aPMN), and IL-6 and IL-8 production when aPMN are in contact with airway epithelial cells. Before coculture, freshly isolated CF aPMN have greater spontaneous and TNF-alpha-induced apoptosis compared with blood PMN from the same CF patients and from aPMN of non-C...

Although sweat conductivity values are well matched with chloride concentrations for cystic fibrosis (CF) diagnosis, sweat conductivity is not accepted as a definitive diagnostic tool but only a screening method. The aim of this study was to compare the sweat chloride measurements and sweat conductivity values of our patients, and to determine cut-off values of conductivity for making or exclud...

Background: Old age is accompanied by impaired musculoskeletal and nervous system, which may result in low mobility and cognitive problems. This study aims to evaluate the relationship between Physical Activity (PA) and Cognitive Function (CF) among the elderly population. Objectives: ?? Materials & Methods: This is a descriptive cross-sectional study conducted on 200 old people who were memb...

OBJECTIVE Serum YKL-40 plays roles in inflammatory and vascular processes. Our aim was to evaluate serum YKL-40 levels in patients with ankylosing spondylitis (AS) and to investigate their potential relationship with arterial stiffness based on carotid-femoral pulse wave velocity (CF-PWV). METHODS Forty-three patients with AS and 41 healthy controls with no history or current signs of cardiov...