Standard chemotherapy is the only systemic treatment for triple-negative breast cancer (TNBC), and despite the good initial response, resistance remains a major therapeutic obstacle. Here, we employed a High-Throughput Screen to identify targeted therapies that overcome chemoresistance in TNBC. We applied short-term paclitaxel treatment and screened 320 small-molecule inhibitors of known target...

eight genotypes of spring safflower (carthamus tinctorius l.) were evaluated for several physiological traits under stress and non-stress water regimes. data were analyzed using principal factor analysis. the factor analysis technique extracted six factors under non-stress conditions. six factors explained about 80% of the total variation, and only 40% of the variance was accounted for by the f...

Analytic expressions were derived for the compressibility factor and residual internal energy of the square-well plus Sutherland fluid. In this derivation, we used the second order Barker-Henderson perturbation theory based on the macroscopic compressibility approximation together with an analytical expression for radial distribution function of the reference hard sphere fluid. These properties...

Underlying fabrics can change the appearance, function and quality of the garment, and also add so much longevity of the garment. Nowadays, with the increasing use of various types of fabrics in the garment industry, their resistance to bagging is of great importance with the aim of determining the effectiveness of textiles under various forces. The current paper investigated the effect of unde...

In this research, residual strength and stress concentration factor of laminated composites with a circular open hole are studied analytically, numerically and experimentally. The numerical study was carried out using the finite element method. Moreover an analytical study was carried out with developing of point stress criterion. Mechanical testing was performed to determine the un-notched ten...

OBJECTIVE To measure Lewis y and integrin α(5)β(1) expression in epithelial ovarian carcinoma and to correlate the levels of these molecules with ovarian carcinoma chemotherapy and prognosis. METHODS The study population included 34 ovarian carcinoma patients with chemotherapeutic drug-resistance, six partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). Immunochemistry was ...

Cancer is a highly complex disease to understand, because it entails multiple cellular physiological systems. The most common cancer treatments are restricted to chemotherapy, radiation and surgery. Moreover, the early recognition and treatment of cancer remains a technological bottleneck. There is an urgent need to develop new and innovative technologies that could help to delineate tumor marg...

The operational impact of deltamethrin resistance on the efficacy of indoor insecticide applications to control Aedes aegypti was evaluated in Merida, Mexico. A randomized controlled trial quantified the efficacy of indoor residual spraying (IRS) against adult Ae. aegypti in houses treated with either deltamethrin (to which local Ae. aegypti expressed a high degree of resistance) or bendiocarb ...

Ten intubated neonates (weights 0.90 to 2.58 kg) recovering from respiratory disease had lung mechanics, respiratory patterns, and functional residual capacity measured at 0 cmH2O continuous positive airways pressure and then after application of serially increasing levels of external expiratory resistance. At an external expiratory resistance greater than 40 cmH2O/1 per second, there was a sig...

OBJECTIVE (1) To evaluate the corrosion resistance of four different orthodontic archwires and to determine the effect of 0.5% NaF (simulating high fluoride-containing toothpaste of about 2250 ppm) on corrosion resistance of these archwires. (2) To assess whether surface roughness (Ra) is the primary factor influencing the corrosion resistance of these archwires. MATERIALS AND METHODS Four di...