Our laboratory is engaged in an ongoing analysis of a 103-compound data set containing reliable intravenous pharmacokinetic parameters in the rat, dog, monkey, and human, and we have previously reported our findings regarding extrapolation of clearance. In this article, we report on our findings regarding volume of distribution and mean residence time. Various allometric and nonallometric metho...

Continuous powder mixing is an efficient alternative in high volume manufacturing of powder-based products. A new method is communicated in this paper to determine the effects of different operating conditions andmixer configurations onmixing performance. Themain idea of the proposedmethodology is the utilization of experimental residence time distribution (RTD) measurements to (a) determine th...

Water exchange mechanisms are assessed via modelling the spatial distribution of the mean residence time in lakes and coastal areas. A grid-based numerical solution of the deterministic advection-diffusion-reaction kinetics equation with the ageing of water as transport variable is applied. The composition of residence time from times spent over separate sub-domains is handled as multi-species ...

We study the distribution of residence time or equivalently that of "mean magnetization" for a family of Gaussian Markov processes indexed by a positive parameter alpha. The persistence exponent for these processes is simply given by theta=alpha but the residence time distribution is nontrivial. The shape of this distribution undergoes a qualitative change as theta increases, indicating a sharp...